Mechanism of ATP hydrolysis dependent rotation of bacterial ATP synthase [PDF]
Nature Communications, 2023 F1 domain of ATP synthase is a rotary ATPase complex in which rotation of central γ-subunit proceeds in 120° steps against a surrounding α3β3 fueled by ATP hydrolysis. How the ATP hydrolysis reactions occurring in three catalytic αβ dimers are coupled to
Atsuki Nakano +3 more
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Defining the role of ATP hydrolysis in mitotic segregation of bacterial plasmids. [PDF]
PLoS Genetics, 2013 Hydrolysis of ATP by partition ATPases, although considered a key step in the segregation mechanism that assures stable inheritance of plasmids, is intrinsically very weak.
Yoan Ah-Seng +3 more
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Structures and mechanisms of actin ATP hydrolysis. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance A variety of cellular functions are driven by actin, which undergoes cyclic transitions between the monomeric G-form and the filamentous F-form.
Kanematsu Y +14 more
europepmc +5 more sources
Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1
eLife, 2017 Hsp90 is a homodimeric ATP-dependent molecular chaperone that remodels its substrate ‘client’ proteins, facilitating their folding and activating them for biological function.
Daniel Elnatan +5 more
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Elucidating Events within the Black Box of Enzyme Catalysis in Energy Metabolism: Insights into the Molecular Mechanism of ATP Hydrolysis by F1-ATPase [PDF]
Biomolecules, 2023 Oxygen exchange reactions occurring at β-catalytic sites of the FOF1-ATP synthase/F1-ATPase imprint a unique record of molecular events during the catalytic cycle of ATP synthesis/hydrolysis.
Sunil Nath
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ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA
eLife, 2015 The cytosolic antiviral innate immune sensor RIG-I distinguishes 5′ tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an incompletely understood mechanism that involves ATP hydrolysis by RIG-I's RNA translocase domain ...
Charlotte Lässig +12 more
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The conformational changes coupling ATP hydrolysis and translocation in a bacterial DnaB helicase
Nature Communications, 2019 DnaB helicases are motor proteins that couple ATP-hydrolysis to the movement of the protein along single-stranded DNA leading to a separation of double-stranded DNA at the replication fork.
Thomas Wiegand +6 more
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ATP Hydrolysis by α‐Synuclein Amyloids is Mediated by Enclosing β‐Strand [PDF]
Advanced SciencePathological amyloids, like those formed by α‐synuclein in Parkinson's disease, are recently found to catalyze the hydrolysis of model substrates in vitro.
Lukas Frey +6 more
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Rotary mechanism of V/A-ATPases—how is ATP hydrolysis converted into a mechanical step rotation in rotary ATPases? [PDF]
Frontiers in Molecular Biosciences, 2023 V/A-ATPase is a rotary molecular motor protein that produces ATP through the rotation of its central rotor. The soluble part of this protein, the V1 domain, rotates upon ATP hydrolysis.
Ken Yokoyama
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Beyond binding change: the molecular mechanism of ATP hydrolysis by F1-ATPase and its biochemical consequences [PDF]
Frontiers in Chemistry, 2023 F1-ATPase is a universal multisubunit enzyme and the smallest-known motor that, fueled by the process of ATP hydrolysis, rotates in 120o steps. A central question is how the elementary chemical steps occurring in the three catalytic sites are coupled to ...
Sunil Nath
doaj +2 more sources