Results 11 to 20 of about 697,459 (324)

ATP-binding and hydrolysis of human NLRP3

Communications Biology, 2022
Analysis of the inflammasome-forming protein NLRP3 provides insights into the function of conserved residues in the ATP-binding site of NLRP3 and the correlation of ATP hydrolysis with inflammasome activation.
Rebecca Brinkschulte, David M. Fußhöller, Florian Hoss, Juan F. Rodríguez-Alcázar, Mario A. Lauterbach, Carl-Christian Kolbe, Melanie Rauen, Semra Ince, Christian Herrmann, Eicke Latz, Matthias Geyer   +10 more
doaj   +3 more sources

ATP Hydrolysis [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Electron transfer precedes ATP hydrolysis during nitrogenase catalysis [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Biological reduction of dinitrogen (N 2 ) to ammonia (NH 3 ) occurs in a select group of bacteria that contain the metalloenzyme nitrogenase. To catalyze this difficult reaction, nitrogenase requires electrons, protons, and ATP. From the earliest studies of nitrogenase,
S. Duval, Karamatullah Danyal, Sudipta Shaw, A. Lytle, D. Dean, B. Hoffman, E. Antony, L. Seefeldt   +7 more
semanticscholar   +4 more sources

ATP-Binding and Hydrolysis in Inflammasome Activation [PDF]

Molecules, 2020
The prototypical model for NOD-like receptor (NLR) inflammasome assembly includes nucleotide-dependent activation of the NLR downstream of pathogen- or danger-associated molecular pattern (PAMP or DAMP) recognition, followed by nucleation of hetero ...
Christina F. Sandall, Bjoern K. Ziehr, Justin A. MacDonald   +2 more
doaj   +3 more sources

Treatment of heterotopic ossification through remote ATP hydrolysis [PDF]

Science Translational Medicine, 2014
Heterotopic ossification induced by injuries and burns is mediated by signaling through the SMAD pathway and can be targeted with topical apyrase.
Jonathan R. Peterson, S. De La Rosa, Oluwatobi N. Eboda, K. Cilwa, Shailesh Agarwal, S. Buchman, P. Cederna, C. Xi, M. Morris, D. Herndon, Wenzhong Xiao, R. Tompkins, P. Krebsbach, Stewart C. Wang, B. Levi   +14 more
semanticscholar   +3 more sources

MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis [PDF]

Nature Communications
The eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while ATP hydrolysis is essential for consecutive steps in pre ...
Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li, Christian Speck   +11 more
doaj   +2 more sources

Snapshots of the maltose transporter during ATP hydrolysis [PDF]

Proceedings of the National Academy of Sciences, 2011
ATP-binding cassette transporters are powered by ATP, but the mechanism by which these transporters hydrolyze ATP is unclear. In this study, four crystal structures of the full-length wild-type maltose transporter, stabilized by adenosine 5′-(β,γ-imido)triphosphate or ADP in conjunction with phosphate analogs
M. Oldham, Jue Chen
semanticscholar   +3 more sources

Structure of the N-terminal Gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis.

PLoS ONE, 2014
Type II DNA topoisomerases are essential enzymes that catalyze topological rearrangement of double-stranded DNA using the free energy generated by ATP hydrolysis.
Frédéric V Stanger, Christoph Dehio, Tilman Schirmer   +2 more
doaj   +2 more sources

Molecular Mechanism of ATP Hydrolysis Catalyzed by p97: A QM/MM Study. [PDF]

J Chem Theory Comput
Szántó JK, Hulm A, Ochsenfeld C.
europepmc   +2 more sources

Mechanism of ADP-Inhibited ATP Hydrolysis in Single Proton-Pumping F_oF₁-ATP Synthase Trapped in Solution. [PDF]

Int J Mol Sci, 2023
Pérez I, Heitkamp T, Börsch M.
europepmc   +3 more sources