In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis [PDF]
The Journal of Cell Biology, 1998 Heat shock protein 90 (Hsp90), an abundant molecular chaperone in the eukaryotic cytosol, is involved in the folding of a set of cell regulatory proteins and in the re-folding of stress-denatured polypeptides.
W. Obermann +4 more
semanticscholar +4 more sources
PLoS ONE, 2014 Type II DNA topoisomerases are essential enzymes that catalyze topological rearrangement of double-stranded DNA using the free energy generated by ATP hydrolysis.
Frédéric V Stanger +2 more
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Kinetic proofreading at single molecular level: Aminoacylation of tRNA^{Ile} and the role of water as an editor [PDF]
, 2013 Proofreading/editing in protein synthesis is essential for accurate translation of information from the genetic code. In this article we present a theoretical investigation of efficiency of a kinetic proofreading mechanism that employs hydrolysis of the ...
Bagchi, Biman, Santra, Mantu
core +12 more sources
Zooming in on ATP Hydrolysis in F1 [PDF]
Journal of Bioenergetics and Biomembranes, 2005 We summarize our current view of the reaction mechanism in F(1)-ATPase as it has emerged from experiment, theory, and computational studies over the last several years. ATP catalysis in the catalytic binding pockets of F(1) takes place without the release of any significant free energy and is efficiently driven by the combined action of two water ...
Klaus Schulten, Markus Dittrich
openaire +3 more sources
Insights into the regulatory function of the ɛ subunit from bacterial F-type ATP synthases: a comparison of structural, biochemical and biophysical data [PDF]
Open Biology, 2018 ATP synthases catalyse the formation of ATP, the most common chemical energy storage unit found in living cells. These enzymes are driven by an electrochemical ion gradient, which allows the catalytic evolution of ATP by a binding change mechanism.
Alexander Krah +2 more
doaj +1 more source
Kinetic and Interaction Studies of Adenosine-5′-Triphosphate (ATP) Hydrolysis with Polyoxovanadates
Metals, 2021 The reactivity of polyoxovanadates towards adenosine-5′-triphosphate (ATP) hydrolysis at pH 2, 4, 6 and 7 is reported. Detailed kinetic investigation of ATP hydrolysis in the presence of polyoxovanadates was performed through multinuclear nuclear ...
Francisco de Azambuja +2 more
doaj +1 more source
ATP hydrolysis in a marine bacterium [PDF]
Journal of Bacteriology, 1978 The membrane-bound adenosine triphosphatase of marine pseudomonad B-16, when solubilized, is able to rebind to depleted membrane residues of the bacterium and to those of Escherichia coli.
P H Calcott, A R Bhatti
openaire +3 more sources
ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione. [PDF]
PLoS ONE, 2015 ABCB10 (ATP binding cassette sub-family B10) is a mitochondrial inner-membrane ABC transporter. ABCB10 has been shown to protect the heart from the impact of ROS during ischemia-reperfusion and to allow for proper hemoglobin synthesis during erythroid ...
Wei Qiu +3 more
doaj +1 more source
Thermodynamics of the ATPase Cycle of GlcV, the Nucleotide-Binding Domain of the Glucose ABC Transporter of Sulfolobus solfataricus [PDF]
, 2006 ATP-binding cassette transporters drive the transport of substrates across the membrane by the hydrolysis of ATP. They typically have a conserved domain structure with two membrane-spanning domains that form the transport channel and two cytosolic ...
Albers, Sonja-Verena, +5 more
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Nucleotide exchange is sufficient for Hsp90 functions in vivo
Nature Communications, 2023 Hsp90 is an essential eukaryotic chaperone that regulates the activity of many client proteins. Current models of Hsp90 function, which include many conformational rearrangements, specify a requirement of ATP hydrolysis.
Michael Reidy +2 more
doaj +1 more source