Results 31 to 40 of about 795,957 (364)

Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

eLife, 2023
Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is incapable of ATP hydrolysis, consistent with a muted role in antiviral defense.
Adedeji M Aderounmu, P Joseph Aruscavage, Bryan Kolaczkowski, Brenda L Bass   +3 more
doaj   +1 more source

Cytoskeletal remodeling slows cross‐bridge cycling and ATP hydrolysis rates in airway smooth muscle

Physiological Reports, 2020
During isometric activation of airway smooth muscle (ASM), cross‐bridge cycling and ATP hydrolysis rates decline across time even though isometric force is sustained.
Philippe Delmotte, Young‐soo Han, Gary C. Sieck   +2 more
doaj   +1 more source

ATP Hydrolysis Induced Conformational Changes in the Vitamin B12 Transporter BtuCD Revealed by MD Simulations. [PDF]

PLoS ONE, 2016
ATP binding cassette (ABC) transporters utilize the energy of ATP hydrolysis to uni-directionally transport substrates across cell membrane. ATP hydrolysis occurs at the nucleotide-binding domain (NBD) dimer interface of ABC transporters, whereas ...
Chao Pan, Jingwei Weng, Wenning Wang
doaj   +1 more source

ATP hydrolysis kinetics and thermodynamics as determinants of calcium oscillation in pancreatic β cells

Physical Review Research, 2022
Cellular ATP plays an important role in the calcium oscillation signal transduction pathway of pancreatic β cells. It triggers oscillation by binding the ATP-sensitive K^{+} channels (K_{ATP}), and maintains the oscillation by providing ATP hydrolysis ...
Yunsheng Sun, Dianjie Li, Congjian Ni, Yingda Ge, Hong Qian, Qi Ouyang, Fangting Li   +6 more
doaj   +1 more source

On the Mechanism of ATP Hydrolysis in F1-ATPase [PDF]

Biophysical Journal, 2003
Most of the cellular ATP in living organisms is synthesized by the enzyme F(1)F(o)-ATP synthase. The water soluble F(1) part of the enzyme can also work in reverse and utilize the chemical energy released during ATP hydrolysis to generate mechanical motion.
Shigehiko Hayashi, Klaus Schulten, Markus Dittrich   +2 more
openaire   +3 more sources

Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

eLife, 2021
Hydrolysis of nucleoside triphosphates releases similar amounts of energy. However, ATP hydrolysis is typically used for energy-intensive reactions, whereas GTP hydrolysis typically functions as a switch.
Taylor B Updegrove, Jailynn Harke, Vivek Anantharaman, Jin Yang, Nikhil Gopalan, Di Wu, Grzegorz Piszczek, David M Stevenson, Daniel Amador-Noguez, Jue D Wang, L Aravind, Kumaran S Ramamurthi   +11 more
doaj   +1 more source

Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis

mBio, 2020
In Escherichia coli, FtsEX coordinates peptidoglycan (PG) synthesis and hydrolysis at the septum. It acts on FtsA in the cytoplasm to promote recruitment of septal PG synthetases and recruits EnvC, an activator of septal PG hydrolases, in the periplasm ...
Shishen Du, Sebastien Pichoff, Joe Lutkenhaus   +2 more
doaj   +1 more source

Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment

Chemical Science, 2016
The efficacy of DOX·HCl against drug resistant human breast cancer cells is enhanced in the presence of a water-soluble pillar[6]arene (WP6) due to the inhibition of ATP hydrolysis upon formation of WP6⊃ATP in cells, providing a novel strategy to ...
Guocan Yu, Jiong Zhou, Jie Shen, Guping Tang, Feihe Huang   +4 more
semanticscholar   +1 more source

How Does F1-ATPase Generate Torque?: Analysis From Cryo-Electron Microscopy and Rotational Catalysis of Thermophilic F1

Frontiers in Microbiology, 2022
The F1-ATPase is a rotary motor fueled by ATP hydrolysis. Its rotational dynamics have been well characterized using single-molecule rotation assays. While F1-ATPases from various species have been studied using rotation assays, the standard model for ...
Hiroyuki Noji, Hiroshi Ueno
doaj   +1 more source

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication [PDF]

, 2015
© 2015, Chang et al.To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
Speck, C
core   +1 more source