Results 81 to 90 of about 795,957 (364)

Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA [PDF]

, 2009
Rad51 is a DNA recombinase functioning in the repair of DNA double-strand breaks and the generation of genetic diversity by homologous recombination (HR).
Antony, Edwin, Ellenberger, Tom, Krejci, Lumir, Lohman, Timothy M., Tomko, Eric J., Xiao, Qi   +5 more
core   +2 more sources

Role of ATP Hydrolysis in Cyanobacterial Circadian Oscillator [PDF]

Scientific Reports, 2017
AbstractA cyanobacterial protein KaiC shows a stable oscillation in its phosphorylation level with approximately one day period when three proteins, KaiA, KaiB, and KaiC, are incubated in the presence of ATP in vitro. During this oscillation, KaiC hydrolyzes more ATP molecules than required for phosphorylation. Here, in this report, a theoretical model
Sumita Das, Masaki Sasai, Tomoki P. Terada   +2 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Coordinated ATP Hydrolysis by the Hsp90 Dimer

Journal of Biological Chemistry, 2001
The Hsp90 dimer is a molecular chaperone with an unusual N-terminal ATP binding site. The structure of the ATP binding site makes it a member of a new class of ATP-hydrolyzing enzymes, known as the GHKL family. While for some of the family members structural data on conformational changes occurring after ATP binding are available, these are still ...
Otmar Hainzl, Paul Muschler, Johannes Buchner, Klaus Richter   +3 more
openaire   +3 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

ATP Hydrolysis Enhances RNA Recognition and Antiviral Signal Transduction by the Innate Immune Sensor, Laboratory of Genetics and Physiology 2 (LGP2)*

Journal of Biological Chemistry, 2012
Background: Laboratory of genetics and physiology 2 (LGP2) is a cytoplasmic RNA receptor required for innate antiviral signaling. Results: LGP2 uses ATP hydrolysis to diversify RNA recognition and enhance antiviral signaling.
Annie M. Bruns, Darja Pollpeter, Nastaran Hadizadeh, Sua Myong, J. Marko, C. Horvath   +5 more
semanticscholar   +1 more source

The ATPase cycle of PcrA helicase and its coupling to translocation on DNA. [PDF]

, 2009
The superfamily 1 bacterial helicase PcrA has a role in the replication of certain plasmids, acting with the initiator protein (RepD) that binds to and nicks the double-stranded origin of replication.
Martinez-Senac, Maria M, Slatter, Andrew F, Toseland, Christopher P, Webb, Martin R   +3 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Nucleotide-dependent activities of FtsA regulate the early establishment of a functional divisome during the Escherichia coli cell cycle

Frontiers in Microbiology, 2023
During cell division in Escherichia coli, the highly conserved tubulin homolog FtsZ polymerizes and assembles into a ring-like structure, called the Z-ring, at the site of septation.
Josiah J. Morrison, Colby N. Ferreira, Evelyn M. Siler, Katie Nelson, Catherine E. Trebino, Benjamin Piraino, Jodi L. Camberg   +6 more
doaj   +1 more source