Results 141 to 150 of about 332,141 (261)

ATP-release pannexin channels are gated by lysophospholipids. [PDF]

Elife
Henze E, Burkhardt RN, Fox BW, Schwertfeger TJ, Gelsleichter E, Michalski K, Kramer L, Lenfest M, Boesch JM, Lin H, Schroeder FC, Kawate T.   +11 more
europepmc   +1 more source

Pannexin1 inhibits autophagy of cisplatin-resistant testicular cancer cells by mediating ATP release. [PDF]

Cell Cycle, 2022
Yuan M, Yao Y, Wu D, Zhu C, Dong S, Tong X.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Connexin-hemichannels-mediated ATP release causes lung injury following chlorine inhalation. [PDF]

Am J Physiol Cell Physiol
Lazrak A, Yu Z, Matalon S.
europepmc   +1 more source

Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma. [PDF]

Cell Death Dis, 2022
Zanoni M, Sarti AC, Zamagni A, Cortesi M, Pignatta S, Arienti C, Tebaldi M, Sarnelli A, Romeo A, Bartolini D, Tosatto L, Adinolfi E, Tesei A, Di Virgilio F.   +13 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells. [PDF]

FEBS Lett
Nomura S, Wang L, Hasuzawa N, Nagayama A, Moriyama S, Ashida K, Moriyama Y, Nomura M, Yamamoto K.   +8 more
europepmc   +1 more source

A 3D-printed, multi-modal microfluidic device for measuring nitric oxide and ATP release from flowing red blood cells. [PDF]

Anal Methods, 2022
Hayter EA, Azibere S, Skrajewski LA, Soule LD, Spence DM, Martin RS.   +5 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

ACPA-Induced ATP release and K⁺ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis. [PDF]

Cell Commun Signal
Cai L, Zhang K, Gao J, Xiao B, Li M, Meng X, Chen Z, Chen X, Chen S, Li J.   +9 more
europepmc   +1 more source