Results 211 to 220 of about 619,710 (391)
Genetics of Response to ECT, TMS, Ketamine and Esketamine
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined.
Clio E. Franklin +18 more
wiley +1 more source
Pbs2 regulates late‐stage macroautophagy in Saccharomyces cerevisiae
Animal Models and Experimental Medicine, EarlyView.The MAPK family member Pbs2 and its role in autophagy. Macroautophagy consists of five key steps: the initiation at the pre‐autophagosomal structure (PAS), elongation of the isolation membrane (IM), maturation of the autophagosome, fusion of autophagosomes with vacuoles, and degradation of autophagic bodies.
Jianing Song +8 more
wiley +1 more source
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
Site-to-site mutational dissection of fission yeast cohesin reveals its dynamics. [PDF]
G3 (Bethesda)Wei Q +5 more
europepmc +1 more source
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, EarlyView.Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel +10 more
wiley +1 more source