Results 271 to 280 of about 619,710 (391)

Identification of a tyrosine residue at a nucleotide binding site in the beta subunit of the mitochondrial ATPase with p-fluorosulfonyl[14C]-benzoyl-5'-adenosine.

, 1978
Frederick Esch, W S Allison
openalex   +1 more source

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

Cell Biology International, EarlyView.
ABSTRACT Calreticulin is a multifunctional protein found in the endoplasmic reticulum lumen that is important for calcium homeostasis and glycoprotein folding. Mutations in exon 9 of the CALR gene are the second most common genetic cause of myeloproliferative neoplasms.
Mifra Faiz, Caitlin Dunstan‐Harrison, Elizabeth C. Ledgerwood   +2 more
wiley   +1 more source

Persistent Renal Oxidative Stress Despite Mannitol Nephroprotection: The Impact of Social-Single Prolonged Stress in Male and Female Rats Exposed to Cisplatin. [PDF]

Cell Biochem Funct
Jung JTK, Klann IP, Fulco BCW, Zborowski VA, Zeni G, Nogueira CW.   +5 more
europepmc   +1 more source

The effect of thyroid hormone on bile salt-independent bile flow and Na+, K+ -ATPase activity in liver plasma membranes enriched in bile canaliculi. [PDF]

, 1976
Thomas J. Layden, James L. Boyer
openalex   +1 more source

Development of CPA‐Catalyzed β‐Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs

Chemistry – A European Journal, EarlyView.
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Natasha Perry, Shehab Eid, Gerold Schmitt‐Ulms, Pavel Nagorny   +3 more
wiley   +1 more source

Pharmacological Inhibition of β Myosin II Disrupts Sarcomere Assembly in Human iPSC‐Derived Cardiac Myocytes

Cytoskeleton, EarlyView.
ABSTRACT Sarcomeres are the fundamental contractile units of striated muscle. The functional roles of the cardiac‐specific myosin heavy chains, MYH6 (α myosin II) and MYH7 (β myosin II) during sarcomere assembly remain controversial. To address this, we utilized a selective MYH7 inhibitor, mavacamten, in combination with siRNA‐mediated knockdown of ...
James B. Hayes, Dylan T. Burnette
wiley   +1 more source

Autosis is a Na+,K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia

Proceedings of the National Academy of Sciences of the United States of America, 2013
Yang Liu, S. Shoji-Kawata, R. Sumpter, Yongjie Wei, V. Ginet, Liying Zhang, B. Posner, Khoa Tran, D. Green, R. Xavier, S. Shaw, P. Clarke, J. Puyal, B. Levine   +13 more
semanticscholar   +1 more source

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

Cytoskeleton, EarlyView.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker, Karen Baker, Marina Ezcurra, Philippe P. Laissue, Lin Wang, Michael A. Geeves, Jennifer M. Tullet, Daniel P. Mulvihill   +7 more
wiley   +1 more source

Contributions of the Na+/K+‐ATPase, NKCC1, and Kir4.1 to hippocampal K+ clearance and volume responses

Glia, 2014
B. R. Larsen, Mette Assentoft, M. Cotrina, S. Hua, M. Nedergaard, K. Kaila, J. Voipio, N. MacAulay   +7 more
semanticscholar   +1 more source

Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors

ChemMedChem, EarlyView.
SARS‐CoV‐2 nsp13 is a promising target to develop effective antivirals. Pursuing the studies, new indolyl derivatives to deepen SARs are designed. The newly synthesized N‐aryl indoles are active vs both nsp13‐associated activities. They exert antiviral activity vs SARS‐CoV‐2 infected cells with no cytotoxicity.
Valentina Noemi Madia, Roberta Emmolo, Elisa Patacchini, Donatella Amatore, Stefania Maloccu, Davide Ialongo, Aurora Albano, Giuseppe Ruggieri, Emanuele Cara, Laura Zarbo, Antonella Messore, Riccardo De Santis, Alessandra Amoroso, Florigio Lista, Francesca Esposito, Enzo Tramontano, Angela Corona, Roberto Di Santo, Roberta Costi   +18 more
wiley   +1 more source