Results 281 to 290 of about 619,710 (391)

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

Journal of Biological Chemistry, 1991
Jonathan LyttonSg, Marisa WestlinS, Michael R. Hanleyll   +2 more
semanticscholar   +1 more source

Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization

ChemMedChem, EarlyView.
A multitier computational strategy discovers potential USP7 inhibitors using similarity‐based virtual screening, physics‐driven molecular simulations, binding free energy estimations, binary QSAR modeling, and steered molecular dynamics analysis. This integrated approach prioritizes and optimizes lead compounds with strong predicted affinity, offering ...
Ehsan Sayyah, Muhammet Eren Ulug, Serdar Durdağı   +2 more
wiley   +1 more source

The vacuolar-type H+-ATPase at a glance – more than a proton pump

Journal of Cell Science, 2014
Michelle E. Maxson, S. Grinstein
semanticscholar   +1 more source

Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer‐Related Pathways

ChemMedChem, Accepted Article.
Continuing our research aimed at discovering new BAG3 modulators as attractive anticancer drug candidates, we performed a screening campaign on an in‐house library, including compounds featuring a large variety of scaffolds. The obtained results induced us to focus on the triazole moiety and, following a stepwise structural refinement of the scaffold ...
Dafne Ruggiero, Eleonora Boccia, Emis Ingenito, Vincenzo Vestuto, Gilda D’Urso, Alessandra Capuano, Agostino Casapullo, Stefania Terracciano, Giuseppe Bifulco, Gianluigi Lauro, Ines Bruno   +10 more
wiley   +1 more source

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann, Dorien J. M. Peters, Amin Rostami‐Hodjegan, Patricia Wilson, Jill Norman, Jill Barber, Zubida M. Al‐Majdoub   +6 more
wiley   +1 more source

ATPase Activity in Phytohemagglutinin

Experimental Biology and Medicine, 1973
Samuel Nochumson, John J. O'Rangers, Nikolay V. Dimitrov   +2 more
openaire   +3 more sources

Synthesis of 19‐Hydroxyarachidonic Acid by Fungal Peroxygenases: An Experimental and Computational Study

ChemSusChem, EarlyView.
An experimental and computational investigation on the regio‐ and enantioselective hydroxylation of arachidonic acid by several unspecific peroxygenases (UPOs) revealed rAaeUPO A77L variant as the most attractive candidate for the selective production of valuable hydroxy‐fatty acids because of its enhanced regio and enantioselectivity and reduced ...
Alejandro González‐Benjumea, Mireia Martínez‐Sugrañes, Miguel Alcalde, Elvira Romero, Víctor Guallar, Martin Floor, Angel T. Martínez, Ana Gutiérrez   +7 more
wiley   +1 more source

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma. [PDF]

Nat Commun
Arnold CS, Alazzi AM, Shunmugam S, Janouškovec J, Berry L, Charital S, Gautier T, Duley S, Jublot D, Lemaire-Vieille C, Cesbron-Delauw MF, Cavailles P, Govin J, Katris NJ, Yamaryo-Botté Y, Botté CY.   +15 more
europepmc   +1 more source

Active/inactive state transitions of mitochondrial ATPase molecules influenced by Mg²⁺, anions and aurovertin

, 1975
Jennifer Moyle, Peter Mitchell
openalex   +1 more source

Interspecific comparisons of anuran embryonic epidermal landscapes and energetic trade‐offs in response to changes in salinity

Developmental Dynamics, EarlyView.
Abstract Background Freshwater salinization is an emerging stressor in amphibian populations, and embryonic stages are most vulnerable. To better understand the variation in embryonic osmoregulation, we challenged embryos of two phylogenetically diverse anuran species, Xenopus laevis and Lithobates (Rana) sylvaticus, along a gradient of non‐lethal ...
Kourtnie Whitfield, Erica J. Crespi
wiley   +1 more source