Results 301 to 310 of about 619,710 (391)

Impact of hyperbilirubinemia on rat cardiomyocyte injury. [PDF]

BMC Cardiovasc Disord
Zhao J, Ye H, Wu X, Wang D, Ke Y, Fang W.   +5 more
europepmc   +1 more source

Structural Biology of Rad50 ATPase ATP-Driven Conformational Control in DNA Double-Strand Break Repair and the ABC-ATPase Superfamily

Cell, 2000
K. Hopfner, A. Karcher, D. Shin, L. Craig, L. Arthur, J. Carney, J. Tainer   +6 more
semanticscholar   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Conformational cycle and small-molecule inhibition mechanism of a plant ABCB transporter in lipid membranes. [PDF]

Sci Adv
Liu Y, Liao M.
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206). [PDF]

Front Pharmacol
Yang H, Li Z, Wu Z, Chen X, Bo L, Patel H, Zhang B, Xiong W, Wang W, Chen ZS.   +9 more
europepmc   +1 more source

Pseudosubstrates of the sarcoplasmic Ca2+-ATPase as tools to study the coupling between substrate hydrolysis and Ca2+ transport

, 1979
Bernard Rossi, Francisco A. Leone, C. Gache, Michel Lazdunski   +3 more
openalex   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

A gain-of-function mutation in ATP6V0A4 drives primary distal renal tubular alkalosis with enhanced V-ATPase activity. [PDF]

J Clin Invest
Peng SQ, Wu QQ, Wang WY, Zhang YL, Zhou RN, Liao J, Wei JX, Yang Y, Shi W, Yang JL, Wang XX, Wei ZY, Sun JX, Huang L, Fan H, Cai H, Wang CK, Li XH, Li TS, Liu BC, Zhang XL, Wang B.   +21 more
europepmc   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source