Results 11 to 20 of about 460,135 (253)

Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]

, 2012
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core   +7 more sources

Cardiovascular Hospitalizations and Resource Use Following Atrial Fibrillation Ablation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Over the next few years, atrial fibrillation (AF)–related morbidity and costs will increase significantly. Thus, it is prudent to examine the impact of AF treatment on health care resource use.
Mehak Dhande, Amr Barakat, Ann Canterbury, Floyd Thoma, Suresh Mulukutla, Ahmet Sezer, Konstantinos N. Aronis, Aditya Bhonsale, Krishna Kancharla, Andrew H. Voigt, Norman C. Wang, Alaa Shalaby, N. A. Mark Estes, Samir Saba, Sandeep K. Jain   +14 more
doaj   +1 more source

Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress

Frontiers in Cardiovascular Medicine, 2021
Aim: The structural and electrical changes in the atrium, also known as atrial remodeling, are the main characteristics of atrial fibrillation (AF). Fibroblast growth factor 21 (Fgf21) is an important endocrine factor, which has been shown to play an ...
Miao Chen, Jiawei Zhong, Zhen Wang, Hongfei Xu, Heng Chen, Xingang Sun, Yunlong Lu, Lu Chen, Xudong Xie, Liangrong Zheng   +9 more
doaj   +1 more source

Ibandronate promotes autophagy by inhibiting Rac1–mTOR signaling pathway in vitro and in vivo

Cell Death Discovery, 2022
We previously reported that ibandronate (IBAN) could improve endothelial function in spontaneously hypertensive rats. However, the mechanism by which IBAN improves endothelial function is unclear.
Jie Han, Jian Yang, Qiqi Wang, Xiang Yin, Zewei Sun, Chaoyang Huang, Guoping Chen, Liangrong Zheng, Dongmei Jiang   +8 more
doaj   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII-δ. [PDF]

Adv Sci (Weinh)
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Bi HL, Gu YH, Ren KW, Yu XH, Xia YL, Yang XL, Li HH.   +6 more
europepmc   +2 more sources

Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology [PDF]

, 2006
We investigated whether post-cardiac surgery (CS) new-onset atrial fibrillation (AF) is predicted by pre-CS atrial cellular electrophysiology, and whether the antiarrhythmic effect of beta-blocker therapy may involve pre-CS pharmacological remodeling ...
Marshall, Gillian E., Russell, Julie A., Pau, David, Kane, Kathleen A., Workman, Antony J., Rankin, Andrew C., Redpath, Calum J., Norrie, John   +7 more
core   +5 more sources

Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study

BMC Medical Genomics, 2022
Background Observational studies have suggested that obstructive sleep apnea (OSA) is in relation to atrial fibrillation (AF); however, these studies might be confounded and whether the relationship is causal remains unclear. We conducted a bidirectional
Lu Chen, Xingang Sun, Yuxian He, Yunlong Lu, Liangrong Zheng   +4 more
doaj   +1 more source

Picking the Locked Door

JACC: Case Reports, 2023
The management of atrial septal defects (ASDs) has been revolutionized by the advent of percutaneous transvenous occlusion devices. This case series describes techniques required to perform a transeptal puncture safely and effectively in patients ...
Noel Fitzpatrick, MB, MSc, John Keaney, MD, Edward Keelan, MB, Kevin P. Walsh, MD, Gábor Széplaki, PhD   +4 more
doaj   +1 more source

Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology

Journal of Arrhythmia, 2020
Background Catheter ablation is an important rhythm control therapy in patients with atrial fibrillation (AF) with concomitant heart failure (HF). The objective of this study was to assess the comparative efficacy of AF ablation patients with ischemic vs
Eric Black‐Maier, Benjamin A. Steinberg, Kevin M. Trulock, Frances Wang, Yuliya Lokhnygina, Wanda O'Neal, Sana Al‐Khatib, Brett D. Atwater, James P. Daubert, Camille Frazier‐Mills, Donald D. Hegland, Kevin P. Jackson, Larry R. Jackson, Jason I. Koontz, Robert K. Lewis, Albert Y. Sun, Kevin L. Thomas, Tristram D. Bahnson, Jonathan P. Piccini   +18 more
doaj   +1 more source

Catheter ablation of atrial fibrillation in patients with diabetes mellitus

Heart Rhythm O2, 2020
Background: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM.
Allen Wang, MD, Tracy Truong, MB, Eric Black-Maier, MD, Cynthia Green, PhD, Kristen B. Campbell, PharmD, Adam S. Barnett, MD, Janice Febre, BSN, RN, Zak Loring, MD, MHS, Sana M. Al-Khatib, MD, MHS, FHRS, Brett D. Atwater, MD, James P. Daubert, MD, FHRS, Camille Frazier-Mills, MD, MHS, Donald D. Hegland, MD, Kevin P. Jackson, MD, Larry R. Jackson, MD, Jason I. Koontz, MD, PhD, Robert K. Lewis, MD, PhD, Sean D. Pokorney, MD, MBA, Albert Y. Sun, MD, Kevin L. Thomas, MD, Tristam D. Bahnson, MD, FHRS, Jonathan P. Piccini, MD, MHS, FHRS   +21 more
doaj   +1 more source