Results 61 to 70 of about 694,618 (329)

The safety of direct transeptal puncture using a radiofrequency guidewire combined with a 17Fr pulsed field ablation sheath

Scientific Reports
Transseptal puncture (TSP) is widely used in catheter-based cardiac interventions to gain left atrial (LA) access, but its workflow has remained largely unchanged and is still a source of serious complications.
Gael Jauvert, Robert N. Kerley, Noel Fitzpatrick, Jim O’Brien, Fionnuala Seaver, Lorena Rosalejos, Diana Arellano, Kristine Laurilla, Ted Keelan, Joe Galvin, Tamas Tahin, Gabor Szeplaki   +11 more
doaj   +1 more source

Association of the ICH Score With Withdrawal of Life‐Sustaining Treatment Over a 10‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life‐sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.
Nina Massad, Lili Zhou, Brian Manolovitz, Negar Asdaghi, Hannah Gardener, Hao Ying, Carolina M. Gutierrez, Angus Jameson, David Rose, Mohan Kottapally, Amedeo Merenda, Kristine O'Phelan, Sebastian Koch, Jose G. Romano, Tatjana Rundek, Ayham Alkhachroum   +15 more
wiley   +1 more source

Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald, Michela Guglieri, Dragana Vučinić, Gyula Acsadi, John F. Brandsema, Claudio Bruno, Erika L. Finanger, Amy Harper, Mercedes Lopez Lobato, Riccardo Masson, Nuria Muelas, Francina Munell, Yoram Nevo, Yann Péréon, Han Phan, Valeria A. Sansone, Mariacristina Scoto, Tracey Willis, Richard S. Finkel, Krista Vandenborne, Sara Cazzaniga, Silvia Montrasio, Federica Alessi, Paolo Bettica, Eugenio Mercuri, for the Givinostat Study 51 Investigators, the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS) Investigators, the ImagingDMD Investigators, Enrico Bertini, Giacomo Pietro Comi, Eugenio Maria Mercuri, Giuseppe Vita, Sonia Messina, Claudio Bruno, Riccardo Masson, Valeria Sansone, Nathalie Goemans, Liesbeth De Waele, Laurent Servais, Teresa Gidaro, Odile Boespflug‐Tanguy, Yann Péréon, Jessika Johannsen, Astrid Blaschek, Ulrike Schara‐Schmidt, Erik Niks, Imelda de Groot, Saskia Houwen‐van Opstal, Andres Nascimento, Juan Jesus Vilchez, Nuria Muelas, Francina Munell, Marcos Madruga Garrido, Mercedes Lopez Lobato, Michaela Guglieri, Tracey Willis, Stefan Spinty, Daniel Hawcutt, Mariacristina Scoto, Jean K. Mah, Laura McAdam, Kathryn Selby, Katherine Mathews, Craig McDonald, Craig Zaidman, Barry Byrne, John Brandsema, Gyula Acsadi, Chamindra Laverty, Amy Harper, Erika Finanger, Han Phan, Yoram Nevo, Vedrana Milic Rasic, Dragana Vucinic   +74 more
wiley   +1 more source

Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation.

New England Journal of Medicine, 2020
BACKGROUND Guidelines recommend a trial of one or more antiarrhythmic drugs before catheter ablation is considered in patients with atrial fibrillation. However, first-line ablation may be more effective in maintaining sinus rhythm. METHODS We randomly
J. Andrade, G. Wells, M. Deyell, M. Bennett, V. Essebag, J. Champagne, J. Roux, D. Yung, A. Skanes, Y. Khaykin, C. Morillo, U. Jolly, P. Novak, Evan Lockwood, G. Amit, P. Angaran, J. Sapp, Stephan Wardell, S. Lauck, L. Macle, A. Verma   +20 more
semanticscholar   +1 more source

Treatment timing and the effects of rhythm control strategy in patients with atrial fibrillation: nationwide cohort study

British medical journal, 2021
Objective To investigate whether the results of a rhythm control strategy differ according to the duration between diagnosis of atrial fibrillation and treatment initiation. Design Longitudinal observational cohort study.
Daehoon Kim, Pil‐Sung Yang, S. You, J. Sung, E. Jang, H. Yu, Tae‐Hoon Kim, H. Pak, Moon‐Hyoung Lee, G. Lip, B. Joung   +10 more
semanticscholar   +1 more source

Ablation of atrial fibrillation

Current Cardiology Reports, 2006
Fueled by dissatisfaction with pharmacologic strategies to treat atrial fibrillation (AF), the results of basic and clinical investigation into the understanding of AF initiation and maintenance mechanisms, and the explosive development in catheter-based technologies, AF ablation has matured from a purely investigational technique to a preferred, safe,
Pappone C, Santinelli V
openaire   +6 more sources

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation.

New England Journal of Medicine, 2020
BACKGROUND In patients with symptomatic paroxysmal atrial fibrillation that has not responded to medication, catheter ablation is more effective than antiarrhythmic drug therapy for maintaining sinus rhythm.
O. Wazni, G. Dandamudi, Nitesh A. Sood, R. Hoyt, J. Tyler, Sarfraz A. Durrani, M. Niebauer, Kevin J. Makati, B. Halperin, A. Gauri, G. Morales, M. Shao, J. Cerkvenik, R. Kaplon, S. Nissen   +14 more
semanticscholar   +1 more source

Atrial fibrillation in the elderly.

Journal of geriatric cardiology : JGC, 2017
1.581 JCR (2017) Q3, 89/128 Cardiac and Cardiovascular Systems; Q4, 40/53 Geriatrics and ...
Martínez Sellés Oliveria Soares, Manuel, Bayés de Luna, A.   +1 more
openaire   +6 more sources

Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.
Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu   +14 more
wiley   +1 more source