Results 221 to 230 of about 65,035 (251)

Atrial fibrosis progression in patients with no history of atrial fibrillation

Journal of Cardiovascular Electrophysiology, 2021
AbstractBackgroundUnexpected high levels of atrial fibrosis are found in individuals with no history of atrial fibrillation (AF). The temporal behavior of atrial fibrosis in this population is still unknown. We sought to investigate the progression and predictors of atrial fibrosis in non‐AF individuals.MethodsNon‐AF individuals at baseline who ...
Hanyuan Shi, Yan Zhao, Lilas Dagher
exaly   +3 more sources

EZH2 as a novel therapeutic target for atrial fibrosis and atrial fibrillation

Journal of Molecular and Cellular Cardiology, 2019
Angiotensin II (Ang-II)-induced fibroblast differentiation plays an important role in the development of atrial fibrosis and atrial fibrillation (AF). Here, we show that the expression of the histone methyltransferase enhancer of zeste homolog 2 (EZH2) is increased in atrial muscle and atrial fibroblasts in patients with AF, accompanied by significant ...
, Binfeng Mo
exaly   +3 more sources

Atrial fibrosis: a risk stratifier for atrial fibrillation

Expert Review of Cardiovascular Therapy, 2013
Atrial fibrillation (AF), especially persistent and long-standing persistent AF, may result in electro-anatomical changes in the left atrium, resulting in remodeling and deposition of fibrous tissue. There are emerging data that atrial substrate modification may increase the risk of thromboembolic complications, including stroke.
Poonam, Velagapudi, Mohit K, Turagam, Miguel A, Leal, Abraham G, Kocheril   +3 more
openaire   +2 more sources

Atrial Arrhythmias in Endomyocardial Fibrosis

Cardiology, 2008
Atrial arrhythmias occurred in 34 out of 97 patients with endomyocardial fibrosis. In 21 instances, atrial fibrillation or flutter was persistent. In 13 cases, atrial arrhythmia was transient and intermittent. It was necessary, in some patients with rapid ventricular re sponses, to employ direct-current cardioversion.
K, Somers, R F, Gunstone, A K, Patel, P G, D'Arbela   +3 more
openaire   +2 more sources

An Atrial fibrosis-based Approach for Atrial Fibrillation Ablation

Future Cardiology, 2015
Since the emergence of atrial fibrillation (AF) ablation as a reliable method of restoring sinus rhythm, various approaches have been used to improve the efficacy while maximizing the safety of ablation. A major hurdle to optimizing outcomes for AF ablation has been the failure to recognize that the substrate of the individual patient plays a ...
Frederick T, Han, Nassir, Marrouche
openaire   +2 more sources

Left Atrial Fibrosis and Recurrent Arrhythmia

JAMA, 2014
In the Delayed-Enhancement MRI Determinant of Successful Radiofrequency Catheter Ablation of Atrial Fibrillation (DECAAF) study, Dr Marrouche and colleagues1 demonstrated that assessment of left atrial fibrosis with delayed enhancement magnetic resonance imaging (MRI) was associated with the likelihood of recurrent arrhythmia after catheter ablation ...
Tops, L.F., Schalij, M.J.
openaire   +3 more sources

Hypercoagulability Promotes Atrial Fibrosis and Fibrillation

Blood, 2014
Abstract Background: It is well known that atrial fibrillation (AF) induces a hypercoagulable state, which significantly increases stroke risk in patients with AF contributing to morbidity and mortality in these patients. Active coagulation factors can also provoke diverse cellular responses through stimulation of protease-activated ...
Spronk, Henri M.H., De Jong, Anne-Margreet, De Boer, Hetty C., Maas, Alexander, Verheule, Sander, Rienstra, Michiel, Kamphuisen, Pieter W., Ten Cate, Hugo, Crijns, Harry J., Van Gelder, Isabelle, Van Zonneveld, Anton Jan, Schotten, Ullrich   +11 more
openaire   +2 more sources

Biomarkers Associated with Atrial Fibrosis and Remodeling

Current Medicinal Chemistry, 2019
Atrial fibrillation is the most common rhythm disturbance encountered in clinical practice. Although often considered as solely arrhythmic in nature, current evidence has established that atrial myopathy constitutes both the substrate and the outcome of atrial fibrillation, thus initiating a vicious, self-perpetuating cycle.
Polychronis, Dilaveris, Christos-Konstantinos, Antoniou, Panagiota, Manolakou, Eleftherios, Tsiamis, Konstantinos, Gatzoulis, Dimitris, Tousoulis   +5 more
openaire   +2 more sources

Left Ventricular Fibrosis in Atrial Fibrillation

The American Journal of Cardiology, 2013
Excessive atrial fibrosis is involved in the pathogenesis of atrial fibrillation (AF), but little is known of left ventricular (LV) fibrotic status in patients with AF. In the present study, we investigated the presence of abnormal LV fibrosis in AF, its effect on cardiac function, a possible association with arterial stiffness (i.e., systemic ...
Eduard, Shantsila, Alena, Shantsila, Andrew D, Blann, Gregory Y H, Lip   +3 more
openaire   +2 more sources

BRD4 as a therapeutic target for atrial fibrosis and atrial fibrillation

European Journal of Pharmacology
This study aimed to elucidate the molecular mechanisms by which BRD4 play a role in atrial fibrillation (AF).We used a discovery-driven approach to detect BRD4 expression in the atria of patients with AF and in various murine models of atrial fibrosis.
Shuai Song, Jiali Yuan, Guojian Fang, Yingze Li, Shiao Ding, Yuepeng Wang, Qunshan Wang   +6 more
openaire   +2 more sources