Results 131 to 140 of about 19,328,196 (346)

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Long-Term Outcome of Left Heart Function after Catheter Ablation in Patients with Persistent Atrial Fibrillation Combined with Preserved Ejection Fraction Heart Failure

Journal of Interventional Cardiology
Objective. We aimed to examine the benefits of catheter ablation on left heart structure and function in patients with persistent atrial fibrillation (AF) accompanied by heart failure (HF) with preserved ejection fraction (HFpEF), in comparison with the ...
Qian Liu, Yan Zhang, Yanlei Zhao, Ling You, Jinglan Wu, Hongning Yin, Ruiqin Xie   +6 more
doaj   +1 more source

Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.

PLoS ONE, 2014
Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction ...
Yiguo Sun, Matthew D Hills, Willy G Ye, Xiaoling Tong, Donglin Bai   +4 more
doaj   +1 more source

Engineering a Bioelectronic Hybrid Heart with Integrated Sensing and Electrical Modulation

Advanced Science, EarlyView.
A bioelectronic hybrid heart is engineered by integrating iPSC‐derived cardiomyocytes, a decellularized cardiac scaffold, a cell‐laden ECM coating, and a flexible electronic mesh. The embedded electrodes enable real‐time recording of spontaneous electrical activity and localized stimulation, allowing controlled pacing and modulation of activation ...
Itai Cabilly, Hadas Oved, Ron Feiner, Nadav Noor, Moran Yadid, Melanie Flury, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Left atrial appendage function evaluated by transesophageal echocardiography in patients with atrial fibrillation.

Revista Cubana de Cardiología y Cirugía Cardiovascular, 2011
Recurrences of atrial fibrillation in patients with embolic events lead the study of the left atrial appendage, where 90% of thrombus arelodged.To evaluate the function of the left atrial appendage in patients with atrial fibrillation.An observational ...
Raymid García Fernández, Juan Valiente Mustelier, Biolkis Sorio Valdés, Raúl Díaz Padrón Camejo, Teddy O. Tamargo Barbeito, Edsel Gutiérrez Chiguanto, Reinel Álvarez Plasencia   +6 more
doaj  

Left Atrial Structure and Function, and Left Ventricular Diastolic Dysfunction: JACC State-of-the-Art Review.

Journal of the American College of Cardiology, 2019
Defining left atrial (LA) function has recently emerged as a powerful parameter, particularly in evaluation of left ventricular (LV) diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction.
L. Thomas, T. Marwick, B. Popescu, E. Donal, L. Badano   +4 more
semanticscholar   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Effect of atrial fibrillation ablation on left atrial contractile function in patients with paroxysmal atrial fibrillation and a relatively well preserved atrial function

Acta Cardiologica, 2009
There are inconsistent findings regarding the impact of ablation for atrial fibrillation (AF) on left atrial (LA) contractile function. We investigated the ablation effect on LA function in patients with paroxysmal AF.Two hundred eighty-nine patients (mean age 56 +/- 9 years) underwent catheter ablation for paroxysmal AF.
Dagres, N., Hindricks, G., Kottkamp, H., Varounis, C., Bode, K., Arya, A., Sommer, P., Kremastinos, D.Th., Piorkowski, C.   +8 more
openaire   +3 more sources

Oral Bisphosphonates and Risk of Atrial Fibrillation and Flutter in Women: A Self-Controlled Case-Series Safety Analysis [PDF]

, 2009
Background: A recent trial unexpectedly reported that atrial fibrillation, when defined as serious, occurred more often in participants randomized to an annual infusion of the relatively new parenteral bisphosphonate, zoledronic acid, than among those ...
Aroon Hingorani, Douglas, I, Hingorani, A, Douglas, Ian, MacAllister, Raymond, Grosso, Anthony, MacAllister, R, Anthony Grosso, Liam Smeeth, Smeeth, Liam, Raymond MacAllister, Grosso, A, Smeeth, L, Ian Douglas, Hingorani, Aroon   +14 more
core   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source