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The Atrial Natriuretic Factor in Hypertension

The American Journal of the Medical Sciences, 1988
Plasma immunoreactive atrial natriuretic factor (IR-ANF) concentration measured by radioimmunoassay after extraction on Sep-Pak cartridges was studied in 64 control normotensive subjects, 25 patients with labile essential hypertension, 67 patients with mild essential hypertension (diastolic pressure between 90 and 105 mm Hg and no left ventricular ...
J, Genest   +5 more
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Atrial natriuretic factor

Life Sciences, 1985
Mammalian atria contain different peptides with potent diuretic, natriuretic, smooth muscle relaxing and blood pressure lowering properties. A preprohormone of these peptides is synthetized and stored in specific granules in atrial myocytes. Different peptides have been isolated, analyzed and in vitro synthetized.
R, Palluk, W, Gaida, W, Hoefke
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The Heart and the Atrial Natriuretic Factor*

Endocrine Reviews, 1985
The search for natriuretic hormones or factors by studies of negative pressure breathing, atrial distension experiments, head-out water immersion, expansion of blood volume, Na+/K+-ATPase inhibitors and parabiosis experiments in Dahl rats has led to the finding that the atria are a peptide-secreting endocrine gland. This new natriuretic hormone has now
M, Cantin, J, Genest
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Atrial Natriuretic Factor Receptors

Endocrinology and Metabolism Clinics of North America, 1987
All of the actions of atrial natriuretic factor (ANF) can be explained on the basis of ANF's interaction with specific receptors on the plasma membrane of cells in target tissues. These receptors have been identified. Binding to these receptors by ANF is time dependent and specific and occurs with high affinity.
J W, Jacobs, G P, Vlasuk, M, Rosenblatt
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Receptors of Atrial Natriuretic Factor

Annual Review of Physiology, 1992
Atrial natriuretic factor (ANF) is a polypeptide hormone that is secreted mainly by the heart atria in response to increases in atrial pressure or atrial stretch. ANF has multiple actions in the kidney that lead to increases in glomerular filtration rate and excretion of fluid and electrolytes, modulation of renal vascular resistance, decreases in ...
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