Results 1 to 10 of about 9,866 (257)

Intrarenal Mechanisms of Sodium-Glucose Cotransporter-2 Inhibitors on Tubuloglomerular Feedback and Natriuresis [PDF]

Endocrinology and Metabolism, 2023
When sodium-glucose cotransporter-2 (SGLT2) inhibitors were first introduced a decade ago, no one expected them to have substantial effects beyond their known glucose-lowering effects, until the emergence of evidence of their robust renal and ...
Eun Sil Koh, Gheun-Ho Kim, Sungjin Chung
doaj   +2 more sources

Current Understanding of Pressure Natriuresis

Electrolytes & Blood Pressure, 2021
Pressure natriuresis refers to the concept that increased renal perfusion pressure leads to a decrease in tubular reabsorption of sodium and an increased sodium excretion.
E. Baek, Sejoong Kim
semanticscholar   +3 more sources

Natriuresis-guided diuretic therapy in acute heart failure: a pragmatic randomized trial

Nature Medicine, 2023
In patients with acute heart failure, personalized dosing of a diuretic led to treatment intensification in the majority of patients and improved natriuresis, but had no effects on time to all-cause mortality or heart failure rehospitalization ...
Adriaan A Voors, Douwe Postmus, Peter van der Meer   +2 more
exaly   +2 more sources

Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance

European Journal of Heart Failure, 2019
To investigate the effects of acetazolamide on natriuresis, decongestion, kidney function and neurohumoral activation in acute heart failure (AHF).
Koen Ameloot, Wilfried Mullens, Matthias Dupont   +2 more
exaly   +2 more sources

Renal function and natriuresis-guided diuretic therapy – a pre-specified analysis from the PUSH-AHF trial

European Journal of Heart Failure
In a randomized controlled trial, we recently showed that a natriuresis‐guided diuretic approach improved natriuresis and diuresis in patients with acute heart failure (HF).
Adriaan A Voors, Peter van der Meer, Kevin Damman   +2 more
exaly   +2 more sources

AT2 Receptor Activation Induces Natriuresis and Lowers Blood Pressure

Circulation Research, 2014
Rationale: Compound 21 (C-21) is a highly selective nonpeptide AT2 receptor (AT2R) agonist. Objective: To test the hypothesis that renal proximal tubule AT2Rs induce natriuresis and lower blood pressure in Sprague-Dawley rats and mice.
Robert Carey, Shetal H Padia, Brandon A Kemp   +2 more
exaly   +2 more sources

Protocolized Natriuresis-Guided Decongestion Improves Diuretic Response: The Multicenter ENACT-HF Study

Circulation: Heart Failure
Background: The use of urinary sodium to guide diuretics in acute heart failure is recommended by experts and the most recent European Society of Cardiology guidelines. However, there are limited data to support this recommendation.
Nawal Doghmi, Isabel Zegri-Reiriz, Wilfried Mullens   +2 more
exaly   +2 more sources

Logical Issues With the Pressure Natriuresis Theory of Chronic Hypertension.

American Journal of Hypertension, 2016
Stephen E DiCarlo, Theodore W Kurtz, R Curtis Morris   +2 more
exaly   +2 more sources

Pressure-Natriuresis Response Is Diminished in Old Age

Frontiers in Cardiovascular Medicine, 2022
BackgroundAge-related alterations in renal sodium handling affect blood pressure (BP). We aimed to clarify whether the pressure-natriuresis response changes with age, leading to BP elevation.MethodsA total of 4,859 participants with normal renal function
Yang Gyun Kim, Ju-Young Moon, Bermseok Oh, Ho Jun Chin, Dong Ki Kim, Jung Hwan Park, Sung Joon Shin, Bum Soon Choi, Chun Soo Lim, Sang Ho Lee   +9 more
doaj   +1 more source

Sensory Afferent Renal Nerve Activated Gαi2 Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges

Frontiers in Physiology, 2021
We have previously reported that brain Gαi2 subunit proteins are required to maintain sodium homeostasis and are endogenously upregulated in the hypothalamic paraventricular nucleus (PVN) in response to increased dietary salt intake to maintain a salt ...
Jesse D. Moreira, Jesse D. Moreira, Kayla M. Nist, Kayla M. Nist, Casey Y. Carmichael, Casey Y. Carmichael, Jill T. Kuwabara, Jill T. Kuwabara, Richard D. Wainford, Richard D. Wainford   +9 more
doaj   +1 more source