Results 1 to 10 of about 12,547 (268)
Intrarenal Mechanisms of Sodium-Glucose Cotransporter-2 Inhibitors on Tubuloglomerular Feedback and Natriuresis [PDF]
Endocrinology and Metabolism, 2023 When sodium-glucose cotransporter-2 (SGLT2) inhibitors were first introduced a decade ago, no one expected them to have substantial effects beyond their known glucose-lowering effects, until the emergence of evidence of their robust renal and ...
Eun Sil Koh, Gheun-Ho Kim, Sungjin Chung
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Pressure-Natriuresis Response Is Diminished in Old Age
Frontiers in Cardiovascular Medicine, 2022 BackgroundAge-related alterations in renal sodium handling affect blood pressure (BP). We aimed to clarify whether the pressure-natriuresis response changes with age, leading to BP elevation.MethodsA total of 4,859 participants with normal renal function
Yang Gyun Kim +9 more
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Frontiers in Physiology, 2021 We have previously reported that brain Gαi2 subunit proteins are required to maintain sodium homeostasis and are endogenously upregulated in the hypothalamic paraventricular nucleus (PVN) in response to increased dietary salt intake to maintain a salt ...
Jesse D. Moreira +9 more
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Acclimation to a High‐Salt Diet Is Sex Dependent
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Premenopausal women are less likely to develop hypertension and salt‐related complications than are men, yet the impact of sex on mechanisms regulating Na+ homeostasis during dietary salt challenges is poorly defined.
Eman Y. Gohar +14 more
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Effects of Nifedipine on Renal and Cardiovascular Responses to Neuropeptide Y in Anesthetized Rats
Molecules, 2021 Neuropeptide Y (NPY) acts via multiple receptor subtypes termed Y1, Y2 and Y5. While Y1 receptor-mediated effects, e.g., in the vasculature, are often sensitive to inhibitors of L-type Ca2+ channels such as nifedipine, little is known about the role of ...
Angela Bischoff +2 more
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Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses
Journal of Veterinary Internal Medicine, 2023 Background Treatment with phenylbutazone (nonselective COX inhibitor) decreases the diuretic and natriuretic effects of furosemide by nearly 30% but the effects of COX‐2 specific inhibitors (firocoxib) and atypical NSAIDs (dipyrone) are unknown ...
Julianne M. White +2 more
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Novel Antihypertension Mechanism of β-Glucan by Corin and ANP-Mediated Natriuresis in Mice
Mycobiology, 2020 Many of the β-glucans are known to have antihypertensive activities, but, except for angiotensin-converting enzyme II inhibition, the underlying mechanisms remain unclear. Corin is an atrial natriuretic peptide (ANP)-converting enzyme.
Sun Jung Lee, Dong Hee Lee, Ha Won Kim
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Kidney Medicine, 2022 Rationale & Objective: Heart failure treatment relies on loop diuretics to induce natriuresis and decongestion, but the therapy is often limited by diuretic resistance.
Jonathan G. Amatruda +6 more
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Sex-Specific Computational Models of Kidney Function in Patients With Diabetes
Frontiers in Physiology, 2022 The kidney plays an essential role in homeostasis, accomplished through the regulation of pH, electrolytes and fluids, by the building blocks of the kidney, the nephrons.
Sangita Swapnasrita +3 more
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Vanadate-stimulated natriuresis [PDF]
Nature, 1978 THE observation1–3 that V(v) is a potent inhibitor of (Na+, K+)-activated renal ATPase raised the possibility that it has natriuretic and thus diuretic properties in the living animal. We report here experiments showing that it has.
W E, Balfour, J J, Grantham, I M, Glynn
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