Results 81 to 90 of about 735,284 (303)

Staircase in mammalian muscle without light chain phosphorylation

Brazilian Journal of Medical and Biological Research, 1999
In disuse atrophied skeletal muscle, the staircase response is virtually absent and light chain phosphorylation does not occur. The purpose of the present study was to determine if staircase could be restored in atrophied muscle with continued absence of
Rassier D.E., Tubman L.A., MacIntosh B.R.   +2 more
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Functional and Structural Adaptations of Skeletal Muscle to Microgravity [PDF]

, 2001
Our purpose is to summarize the major effects of space travel on skeletal muscle with particular emphasis on factors that alter function. The primary deleterious changes are muscle atrophy and the associated decline in peak force and power.
Fitts, Robert, Riley, Danny R, Widrick, Jeffrey J   +2 more
core   +1 more source

Diagnosis and management of iridocorneal endothelial syndrome [PDF]

, 2015
The iridocorneal endothelial (ICE) syndrome is a rare ocular disorder that includes a group of conditions characterized by structural and proliferative abnormalities of the corneal endothelium, the anterior chamber angle, and the iris.
Ambrosio, Oriella, Macchi, Ilaria, Mantelli, Flavio, Marenco, Marco, Rama, Paolo, SACCHETTI, MARTA   +5 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Clinical presentation of juvenile Huntington disease

Arquivos de Neuro-Psiquiatria, 2006
OBJECTIVE: To describe the clinical presentation a group of patients with juvenile onset of Huntington disease. METHOD: All patients were interviewed following a structured clinical questioner.
Ruocco Heloísa H., Lopes-Cendes Iscia, Laurito Tiago L., Li Li M., Cendes Fernando   +4 more
doaj  

Fast Predictive Simple Geodesic Regression

, 2017
Deformable image registration and regression are important tasks in medical image analysis. However, they are computationally expensive, especially when analyzing large-scale datasets that contain thousands of images.
CR Jack, M Niethammer, M Zhang, MA Ikram, PA Yushkevich, PT Fletcher, X Yang, Y Hong   +7 more
core   +1 more source

Progression of phenotype in Leber's congenital amaurosis with a mutation at the LCA5 locus [PDF]

, 2003
BACKGROUND: Leber’s congenital amaurosis (LCA) accounts for 5% of inherited retinal disease and is usually inherited as an autosomal recessive trait. Genetic and clinical heterogeneity exist.
Inglehearn, C.F., Jafri, H., McKibbin, M.A., Mohamed, M.D., Raashed, Y., Topping, N.C   +5 more
core   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice [PDF]

, 2018
BACKGROUND: Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted by
Alter, Aulino, Ben-David, Bilir, Bonetto, Bonetto, Cornwell, Delitto, Delitto, Dingemans, Fearon, Fearon, Fukawa, Gascan, Graf, Haehling, He, Iseki, Jackman, Jo, Johns, Judge, Kir, Lerner, Loumaye, Martin, Mori, Mori, Onesti, Penna, Petruzzelli, Rubin, Sagar, Schafer, Seto, Stephens, Talbert, Tseng, Villiger, Zhang   +39 more
core   +1 more source