Results 61 to 70 of about 735,284 (303)

Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain. [PDF]

, 2015
Alois Alzheimer is best known for his description of neurofibrillary changes in brain neurons of a demented patient, identifying a novel disease, soon named after him by Kraepelin.
Engelhardt, Eliasz, Grinberg, Lea T
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome

Frontiers in Neurology, 2018
Background and purpose: Whether some gray matter (GM) regions are differentially vulnerable at the early stages of MS is still unknown. The objective of this study is to investigate whether deep and cortical GM are differentially vulnerable after a ...
Ismail Koubiyr, Ismail Koubiyr, Mathilde Deloire, Pierrick Coupé, Cécile Dulau, Pierre Besson, Amandine Moroso, Amandine Moroso, Vincent Planche, Vincent Planche, Vincent Planche, Thomas Tourdias, Thomas Tourdias, Thomas Tourdias, Bruno Brochet, Bruno Brochet, Bruno Brochet, Aurélie Ruet, Aurélie Ruet, Aurélie Ruet   +19 more
doaj   +1 more source

Silent progression in disease activity-free relapsing multiple sclerosis. [PDF]

, 2019
ObjectiveRates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared to natural history studies from the pretreatment era.
Baranzini, Sergio E, Barba, Patrick, Bevan, Carolyn, Bischof, Antje, Bove, Riley, Caverzasi, Eduardo, Cree, Bruce AC, Gelfand, Jeffrey M, Gomez, Refujia, Goodin, Douglas S, Graves, Jennifer, Green, Ari J, Gundel, Tristan, Hauser, Stephen L, Henry, Roland G, Hollenbach, Jill A, Kirkish, Gina, Oksenberg, Jorge R, Papinutto, Nico, Ragan, Nicholas R, Romeo, Andrew, Rush, Gillian Q, Sacco, Simone, Santaniello, Adam, Stern, William A, University of California, San Francisco MS-EPIC Team, Wilson, Michael R, Zamvil, Scott S, Zhao, Chao, Zhu, Alyssa H   +29 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Assessing China’s Situation and Challenges [PDF]

Contemporary Chinese Political Economy and Strategic Relations: An International Journal, 2019
This article intends to assess China’s situation and challenges in the context of its deteriorating external and domestic environments. It focuses on the regime-maintenance initiatives of the Party regime and the prospects for political stability in ...
Joseph Yu-shek Cheng
doaj  

Hippocampus in health and disease: An overview

Annals of Indian Academy of Neurology, 2012
Hippocampus is a complex brain structure embedded deep into temporal lobe. It has a major role in learning and memory. It is a plastic and vulnerable structure that gets damaged by a variety of stimuli.
Kuljeet Singh Anand, Vikas Dhikav
doaj   +1 more source

Long-Term Oral Administration of LLHK, LHK, and HK Alters Gene Expression Profile and Restores Age-Dependent Atrophy and Dysfunction of Rat Salivary Glands

Biomedicines, 2020
Xerostomia, also known as dry mouth, is caused by a reduction in salivary secretion and by changes in the composition of saliva associated with the malfunction of salivary glands. Xerostomia decreases quality of life.
Yasuko Ishikawa, Tomasz D Pieczonka, Aneta M Bragiel-Pieczonka, Harumichi Seta, Tadahiro Ohkuri, Yumi Sasanuma, Yuji Nonaka   +6 more
doaj   +1 more source