Results 41 to 50 of about 497,953 (316)

Survey of changes in subjective symptoms among Japanese polio survivors over 10 years

Journal of Rehabilitation Medicine
Objective: To define long-term changes in subjective symptoms among polio survivors in Japan. Design: Prospective cohort study. Patients: Sixty-five polio survivors.
Fumi Toda, Koshiro Sawada, Daisuke Imoto, Kazuya Hayashi, Shun Fujii, Eiichi Saitoh, Yohei Otaka   +6 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes

Physiological Reports
The antibiotic streptomycin is an integral part of cell culture medium. Because streptomycin inhibits bacterial protein synthesis, streptomycin might also have off‐target effects on muscle cell function.
Chuqi He, Moritz Eggelbusch, Jelle Y. Huijts, Andi Shi, Gerard J. deWit, Carla Offringa, Richard T. Jaspers, Rob C. I. Wüst   +7 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Features of cytokine balance in patients with precancerous gastric lesions depending on the changes in the structure of the thyroid gland

Gastroenterologìa, 2020
Background. The study of the cytokine balance is important due to searching the general links of the pathogenesis of comorbidity in precancerous gastric lesions and thyroid diseases.
L.M. Mosiychuk, I.V. Kushnirenko, O.M. Tatarchuk, I.S. Konenko, O.P. Petishko   +4 more
doaj   +1 more source

Up- and Downregulated Genes after Long-Term Muscle Atrophy Induced by Denervation in Mice Detected Using RNA-Seq

Life, 2023
Skeletal muscle atrophy occurs rapidly as a result of inactivity. Although there are many reports on changes in gene expression during the early phase of muscle atrophy, the patterns of up-and downregulated gene expression after long-term and ...
Shoko Sawano, Misaki Fukushima, Taiki Akasaka, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi, Wataru Mizunoya   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome

Frontiers in Neurology, 2018
Background and purpose: Whether some gray matter (GM) regions are differentially vulnerable at the early stages of MS is still unknown. The objective of this study is to investigate whether deep and cortical GM are differentially vulnerable after a ...
Ismail Koubiyr, Ismail Koubiyr, Mathilde Deloire, Pierrick Coupé, Cécile Dulau, Pierre Besson, Amandine Moroso, Amandine Moroso, Vincent Planche, Vincent Planche, Vincent Planche, Thomas Tourdias, Thomas Tourdias, Thomas Tourdias, Bruno Brochet, Bruno Brochet, Bruno Brochet, Aurélie Ruet, Aurélie Ruet, Aurélie Ruet   +19 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source