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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Solanezumab is a monoclonal antibody that preferentially binds soluble amyloid beta and promotes its clearance from the brain. The aim of this post hoc analysis was to assess the effect of low‐dose solanezumab (400 mg) on global brain volume
Diana Otero Svaldi +8 more
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Archives of Pediatrics & Adolescent Medicine, 1912 The term "atrophy of infants" was formerly used to designate a disease sui generis . It was characterized clinically by the fact that children, who had developed well up to a certain time, gradually began to fail and eventually died, presenting the picture of a progressive and often extreme grade of emaciation.
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Metabolites, 2021 Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly organized junctions between the terminal cisternae of the sarcoplasmic ...
Antonio Michelucci +3 more
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Mayo Clinic Proceedings, 2010 Vulvovaginal atrophy (VVA) is a common and underreported condition associated with decreased estrogenization of the vaginal tissue. Symptoms include dryness, irritation, soreness, and dyspareunia with urinary frequency, urgency, and urge incontinence. It can occur at any time in a woman's life cycle, although more commonly in the postmenopausal phase ...
Maire B, Mac Bride +2 more
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Dissociating memory networks in early Alzheimer's disease and frontotemporal lobar degeneration - a combined study of hypometabolism and atrophy [PDF]
, 2013 Introduction: We aimed at dissociating the neural correlates of memory disorders in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD).
Barbara Vogt +29 more
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A Rare Case of Sporadic Inclusion Body Myositis (s-IBM) [PDF]
Journal of Clinical and Diagnostic Research, 2016 Sporadic inclusion body myositis (s-IBM) is an acquired inflammatory myopathy. Clinical presentation is variable. The usual presentation is progressive weakness and atrophy of the arms and leg muscles, especially of the quadriceps femoris which is ...
Sourya Acharya +4 more
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Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy [PDF]
, 2010 Background: Up to the 1950s, there was an ongoing debate about the diversity of hereditary optic neuropathies, in particular as to whether all inherited optic atrophies can be ascribed to Leber's hereditary optic neuropathy (LHON) or represent different ...
Alexander Christiane +35 more
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Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development [PDF]
, 2016 This work was supported by The RJAH Institute of Orthopaedics, UK (H.F.), The SMA Trust, UK (H.F.), Cedars-Sinai Institutional startup funds (D.S), California Institute for Regenerative Medicine Grant RT-02040 (D.S.), National Center for Advancing ...
Heidi R. Fuller +23 more
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Düzce Tıp Fakültesi Dergisi, 2023 Aim: The aim of the present study was to characterize age-associated changes in the spatial configuration of cerebral hemispheres (including changes in spatial complexity and space-filling capacity) using fractal analysis of silhouette magnetic resonance
Oleksandr Stepanenko, Nataliia Maryenko
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Metabolites, 2022 Lung infection can evoke pulmonary and systemic inflammation, which is associated with systemic severe symptoms, such as skeletal muscle wasting. While N-chlorotaurine (also known as taurine chloramine; TauCl) has anti-inflammatory effects in cells, its ...
Nguyen Khanh Hoang +4 more
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