Results 101 to 110 of about 111,342 (315)
Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]
, 2018 The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J. +14 more
core +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, EarlyView.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models. [PDF]
, 2016 Pulmonary hypertension (PH) is a complex disease comprising a pathologic remodeling and thickening of the pulmonary vessels causing an after load on the right heart ventricle that can result in ventricular failure. Triggered by oxidative stress, episodes
Ahmed, Mohamed +5 more
core +2 more sources
Prenatal Diagnosis, EarlyView.ABSTRACT Objective To describe perinatal and short‐term pediatric outcomes and procedural safety of fetal endoscopic tracheal occlusion (FETO) in a Canadian national referral centre. Methods Retrospective study including all consecutive FETO cases at the Ontario Fetal Centre between 2010 and 2024.
Yada Kunpalin +10 more
wiley +1 more source
Journal of Small Animal Practice, Volume 63, Issue 12, Page 904-910, December 2022., 2022 Two dogs with anorexia and rapid weight loss were referred to our hospital due to a right renal mass and several pulmonary nodules. Both dogs underwent needle core biopsy of the mass, followed by transarterial chemoembolisation of the renal mass. A catheter was inserted from the femoral artery and advanced into the right renal artery.
A. Kimata +8 more
wiley +1 more source
Effect of 0.025% atropine on ocular biometry changes during accommodation. [PDF]
Ophthalmic Physiol OptAbstract Purpose Low concentration atropine is an effective treatment to slow myopia progression and axial elongation and also reduces accommodation. On‐axis ocular dimensions of the eye change during accommodation; hence, this study aimed to quantify the effect of 0.025% atropine eye drops on accommodation‐induced changes in ocular biometry.
Hughes RPJ +4 more
europepmc +2 more sources
On the Use of Atropine in Cholera [PDF]
Journal of the Royal Society of Medicine, 1893 n ...
openaire +3 more sources
Microbiota diversity and differences in the respiratory tract of children with pneumonia
Pediatric Investigation, EarlyView.Differences in microbial communities in the upper and lower respiratory tract in patients with pneumonia were investigated in this study by sequencing the 16S rRNA genes in pharyngeal swabs and alveolar lavage fluid. Forty‐three subjects were enrolled in the study, and one upper and one lower respiratory tract sample were collected from each subject ...
Dandan Ge +4 more
wiley +1 more source
Archives of Academic Emergency Medicine, 2019 Introduction: Atropine is not recommended in organophosphorus (OPs) poisoning cases without any obvious clinical signs. This study aimed to evaluate the clinical utility of Atropine challenge test in screening OPs poisoning cases with atypical ...
Shahin Shadnia +4 more
doaj +1 more source