Results 61 to 70 of about 2,041,165 (290)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Breakup grief: The difference between initiator and non-initiator depending on coping strategies and attachment [PDF]
Zbornik Radova Filozofskog Fakulteta u Prištini, 2020 The aim of this paper is to examine the difference in the intensity of the breakup distress between the initiator and the non-initiator, as well as whether this difference is moderated by coping strategies and inner working models according to the ...
Ranđelović Kristina Ž. +1 more
doaj
Adolescent internet abuse. A study on the role of attachment to parents and peers in a large community sample [PDF]
, 2018 Adolescents are the main users of new technologies and theirmain purpose of use is social interaction. Although new technologies are useful to teenagers, in addressing their developmental tasks, recent studies have shown that they may be an obstacle in ...
Ballarotto, Giulia +3 more
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
CLINICAL PROFILE AND MANAGEMENT OF PATIENTS WITH CARCINOMA GALL BLADDER
Basrah Journal of SurgeryGallbladder cancer (GBC) is an aggressive malignancy with an extremely poor prognosis. It is the most common cancer of the biliary tree. The early symptoms of gallbladder carcinoma are generally nonspecific and often mimic those of more common calculous ...
vinamra mittal +2 more
doaj +1 more source
Scientia Marina, 2016 Although recruitment patterns of Pollicipes pollicipes (Crustacea: Scalpelliformes) in the wild have been investigated, no studies have yet focused on the factors that affect settlement. In the present paper, settlement of P.
Sofia C. Franco +3 more
doaj +1 more source
Statistics of leaders and lead changes in growing networks
, 2009 We investigate various aspects of the statistics of leaders in growing network models defined by stochastic attachment rules. The leader is the node with highest degree at a given time (or the node which reached that degree first if there are co-leaders).
Barrat A +12 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source