Results 41 to 50 of about 17,088 (265)

The mediating role of early maladaptive schemas on the relationship between attachment styles and defense mechanisms

open access: yesمجله علوم روانشناختی, 2019
Background: Attachment styles, early maladaptive schemas and defense mechanisms are the major determinants of psychological problems. Discovering the relationships of these variables has theoretical and clinical importance.
Mohammad Ali Besharat   +2 more
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

The relationship between attachment styles and some social skills of university students [PDF]

open access: yesمجلة بحوث التعليم والإبتكار
The research aimed to investigate the relationship between attachment styles and some social skills among university students. The study sample consisted of (250) male and female university students, aged between (18–23) years, with a mean age of (19.84)
Nesma Ismail Mohamed Saleh
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Infidelity proneness: the role of parenting styles and attachment styles

open access: yesفصلنامه خانواده پژوهی, 2019
This study intends to examine whether the different styles of parenting through the creation of different attachment styles can be effective in marital infidelity proneness.
سولماز جوادی   +1 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Relation of Attachment Styles with Positive and Negative Perfectionism

open access: yesروانشناسی بالینی و شخصیت, 2007
The aim of this study was to examine the relationship between attachment styles and perfectionism. One hundred and seventy students (97 girls, 73 boys) were participated in this study.
M.A. Besharat   +2 more
doaj  

Mediating Role of Cognitive Emotion Regulation Strategies on the Relationship Between Attachment Styles and Alexithymia

open access: yesEurope's Journal of Psychology, 2014
The main objective of the present study was to investigate the mediating role of cognitive emotion regulation strategies on the relationship between attachment styles and alexithymia.
Mohammad Ali Besharat, Vahideh Shahidi
doaj   +1 more source

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