Results 51 to 60 of about 17,088 (265)

Sex differences in attachment styles

Current Opinion in Psychology, 2019
Sex differences in attachment styles have been found in adulthood, emerge as early as middle childhood, and can be sizable when described at the appropriate level of analysis. However, they have received relatively little attention in mainstream attachment research.
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Attachment styles as mediators between autistic traits and psychological distress: The role of social and communication difficulties

Fides et Ratio
Autistic traits such as social skill and communication difficulties are linked to increased risk of depression and anxiety. Attachment theory offers a useful framework for understanding these associations, as insecure attachment styles are known to ...
Agnieszka Siedler, Anna Waligórska
doaj   +1 more source

Measure of Attachment Style

International Journal of Indian Psychology, 2016
This paper describes the development and standardization of a measure of perceived attachment styles. The four attachment styles namely secure, avoidant insecure, ambivalent insecure, and disorganized insecure attachment proposed by Mary Ainsworth (1970), Main and Soloman 1986 (Disorganized- insecure attachment).
null Nasheed Imtiaz, null Azmat Jahan, null Naseem Ahmad   +2 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Medically Unexplained Symptoms and Attachment Theory: The BodyMind Approach®

Frontiers in Psychology, 2019
This article discusses how The BodyMind Approach® (TBMA) addresses insecure attachment styles in medically unexplained symptoms (MUS). Insecure attachment styles are associated with adverse childhood experiences (ACEs) and MUS (Adshead and Guthrie, 2015)
Helen Payne, Susan D. Brooks
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Attachment styles, mental health, and trauma during the first wave of COVID-19 pandemic in an Italian adult population

Research in Psychotherapy
The COVID-19 pandemic has negatively impacted adults’ mental health around the world. Various studies highlighted the role of sociodemographic risk factors, including age, gender, and level of education, in increasing this impact.
Elena Ierardi, Marta Bottini, Emanuele Preti, Rossella Di Pierro, Fabio Madeddu, Cristina Riva Crugnola   +5 more
doaj   +1 more source