Results 71 to 80 of about 301,595 (258)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Family Dynamics and Digital Distractions: A Survey-Based Study on How Co-Parenting and Parental Phubbing Shape Preschoolers’ Media Use

Behavioral Sciences
In the current information era, even preschool children are unable to withstand the “digital flood”. However, excessive exposure to electronic screens not only negatively impacts various aspects of children’s health and adaptation, but also harms family ...
Yuying Zhang, Kuai Song, Gengfeng Niu
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

The Influence of Cleaning Solutions on the Retention of Overdenture Attachment Systems. [PDF]

Biomedicines, 2023
Monteiro S, Barreiros P, Mendes J, Aroso C, Silva AS, Mendes JM.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A comparative clinical study of two different attachment systems and implant stability in implant-supported mandibular overdentures

Dental Journal
Background: Implant stability is crucial for the long-term durability of implant-supported removable dentures. Understanding the clinical impact of attachment systems such as Novaloc and Locator on stability is essential for their potential prognosis ...
Ammar Omar Belal, Moataz Mostafa Bahgat Elmahdy, Sayed Mohammed Mohammed El Masry, Mohamed Ezzat Elsayed   +3 more
doaj   +1 more source

Influence of Denture Cleansers on the Retention Loss of Attachment Systems Retained Implant Overdenture. [PDF]

Int J Biomater, 2023
AlRumaih HS, Albarrak AA, AlMedaires M, Alsulaiman AA, Baba NZ, Alshahrani FA, Alqarawi FK, Al-Dulaijan YA, Alzoubi F, Alhumaidan AA, Gad MM.   +10 more
europepmc   +1 more source