Results 51 to 60 of about 10,005,921 (298)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comparing the swallowing dynamics of mandibular implant overdentures retained with different attachment systems: A crossover study

open access: yesMansoura Journal of Dentistry
Objective This study's objective was to compare the swallowing dynamics for mandibular implant-retained overdentures with different attachment systems Materials and methods for this crossover study, 15 healthy patients were chosen from the outpatient ...
Nermeen Elsayed Mohamed Abdallah   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Examining the importance of the family on pre-school attachment and children's social development [PDF]

open access: yes, 2012
Contemporary accounts of attachment theory are usually provided in terms of the mother-child dyad, isolated from the family. This focus has served to ostracise the caregiving context, once viewed as central to understanding child attachment quality ...
Kennedy, M
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Attachment Styles Within the Coach-Athlete Dyad: Preliminary Investigation and Assessment Development [PDF]

open access: yes, 2013
The present preliminary study aimed to develop and examine the psychometric properties of a new sport-specific self-report instrument designed to assess athletes’ and coaches’ attachment styles. The development and initial validation comprised three main
Jowett, Sophia   +2 more
core   +1 more source

Wear of two different attachment systems in implant supported mandibular overdentures: a clinical comparative study

open access: yesBrazilian Dental Science
Introduction: The stud attachment is regarded as one of the most popular systems for the retention of removable overdentures. A new type of PEEK attachment system, such as Novaloc, may have a good prognosis compared to other systems.
Ammar Omar Belal   +3 more
doaj   +1 more source

Attachment and Parental Practices as Predictors of Behavioral Disorders in Boys and Girls

open access: yesPaidéia (Ribeirão Preto), 2013
This study’s objective was to investigate how two parental systems (attachment and parental practices) interact to predict internalizing and externalizing behavioral problems in girls and boys.
Sandra Adriana Neves Nunes   +2 more
doaj   +1 more source

A Dynamic-Maturational Framework for the Study of Psychosis and Attachment Theory

open access: yesJournal of Experimental Psychopathology, 2022
Attachment theory has been used to explain the origin of psychotic phenomena. In this article we critically evaluate dominant models and assessment measures of attachment in the study of psychosis. We identify four problems aligning to current theory and
Alexander H. Jack, Stephanie Wilson
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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