Results 61 to 70 of about 26,402 (256)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Dynamic Security Assessment Of Computer Networks In Siem-Systems

open access: yesБезопасность информационных технологий, 2015
The paper suggests an approach to the security assessment of computer networks. The approach is based on attack graphs and intended for Security Information and Events Management systems (SIEM-systems).
Elena Vladimirovna Doynikova   +2 more
doaj  

Co-Adaptive Attacker–Defender Learning over Attack Graphs: A Stochastic Game Approach to Dynamic Network Defense

open access: yesFuture Internet
The evolving landscape of cybersecurity threats, characterized by increasingly sophisticated and adaptive attackers, poses major challenges to traditional static network defense mechanisms.
Mohammed A. Makarem   +2 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

GCN-RP: Graph Convolutional Network-Based Predictor for Network Connectivity Resilience

open access: yesIEEE Access
Evaluating the connectivity resilience of real-world networks through attack simulations is a time-consuming process. This study proposes a method that trains Graph Convolutional Networks (GCNs) on synthetic graphs—generated from real graphs ...
Aybike Simsek
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

Using attack graphs to defend healthcare systems from cyberattacks: a longitudinal empirical study. [PDF]

open access: yesNetw Model Anal Health Inform Bioinform, 2022
Ünözkan H, Ertem M, Bendak S.
europepmc   +1 more source

Stem Cell Transplantation in Friedreich Ataxia: Cure for Leukemia but No Effect on Neurological Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Friedreich Ataxia (FRDA) is a neurodegenerative disorder of children and young adults associated with cardiomyopathy and other systemic complications. We report a 10‐year‐old girl who presented simultaneously with Acute Myelogenous Leukemia and FRDA who was successfully treated for her leukemia with allogeneic hematopoietic stem cell ...
Alexandra Gitman   +5 more
wiley   +1 more source

Construction of advanced persistent threat attack detection model based on provenance graph and attention mechanism

open access: yesTongxin xuebao
In response to the difficulty of existing attack detection methods in dealing with advanced persistent threat (APT) with longer durations, complex and covert attack methods, a model for APT attack detection based on attention mechanisms and provenance ...
Yuancheng LI   +3 more
doaj   +2 more sources

FPGAA: A Multi-Feature Provenance Graph for the Accurate Alert System

open access: yesIEEE Access
The detection and traceability research of massive log information has always been a focal point in Advanced Persistent Threats (APT) studies. Causality relationship technology analyzes attack paths and simplifies graph scale by mapping attack behaviors,
Jian Jiao   +4 more
doaj   +1 more source

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