Results 51 to 60 of about 28,264 (289)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Conceptual Abstraction of Attack Graphs - A Use Case of securiCAD

, 2019
Attack graphs quickly become large and challenging to understand and overview. As a means to ease this burden this paper presents an approach to introduce conceptual hierarchies of attack graphs.
Mao, Xinyue, Ekstedt, Mathias,, Ringdahl, Erik,, Robert Lagerström, Mathias Ekstedt, Engla Ling, Erik Ringdahl, Ling, Engla,, Lagerström, Robert,, Xinyue Mao   +9 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Identifying Critical Attack Assets in Dependency Attack Graphs [PDF]

, 2008
Attack graphs have been proposed as useful tools for analyzing security vulnerabilities in network systems. Even when they are produced efficiently, the size and complexity of attack graphs often prevent a human from fully comprehending the information conveyed.
Reginald E. Sawilla, Xinming Ou
openaire   +1 more source

A Probability-based Approach to Attack Graphs Generation

, 2009
Attack graphs are important tools for analyzing network security vulnerabilities. Recently, the generation method of attack graphs is a hot topic to the security researchers.
Zhong Chen, Jianbin Hu, Zhang, Li, Hu, Jianbin, Anming Xie, Chen, Zhong, Xie, Anming, Li Zhang   +7 more
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

An Ant Colony Optimization Algorithm for Network Vulnerability Analysis

Iranian Journal of Electrical and Electronic Engineering, 2006
Intruders often combine exploits against multiple vulnerabilities in order to break into the system. Each attack scenario is a sequence of exploits launched by an intruder that leads to an undesirable state such as access to a database, service ...
M. Abadi, S. Jalili
doaj  

GCN-RP: Graph Convolutional Network-Based Predictor for Network Connectivity Resilience

IEEE Access
Evaluating the connectivity resilience of real-world networks through attack simulations is a time-consuming process. This study proposes a method that trains Graph Convolutional Networks (GCNs) on synthetic graphs—generated from real graphs ...
Aybike Simsek
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source