Results 111 to 120 of about 3,000,348 (321)

The Role of Attention Modulation and Its Neurophysiological Mechanisms in Tinnitus Management: A Review

open access: yesAuditory and Vestibular Research
Background and Aim: Tinnitus, characterized by the perception of sound without the presence of an external auditory stimulus, can profoundly affect the quality of life.
Hossein Namvar Arefi   +3 more
doaj   +1 more source

Neuronal Mechanisms of Visual Attention

open access: yesAnnual Review of Vision Science, 2015
Advances on several fronts have refined our understanding of the neuronal mechanisms of attention. This review focuses on recent progress in understanding visual attention through single-neuron recordings made in behaving subjects. Simultaneous recordings from populations of individual cells have shown that attention is associated with changes in the ...
openaire   +4 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Improvement strategies of athlete’s concentration level based on visual attention model

open access: yesScientific Reports
Different athletes have different requirements and coping methods for concentration. Research based on visual attention models can help identify individual differences and propose targeted improvement strategies to improve the concentration level of each
Jiabao Cui   +6 more
doaj   +1 more source

HDA-Net: H&E and RGB Dual Attention Network for Nuclei Instance Segmentation

open access: yesIEEE Access
H&E-stained images (HSIs) are widely adopted for revealing cellular structures and capturing morphological changes in nuclear instance segmentation.
Yu-Han Im   +2 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

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