Live-attenuated Vaccines Prevent Respiratory Syncytial Virus-associated Illness in Young Children. [PDF]
Am J Respir Crit Care Med, 2021 RATIONALE Active immunization is needed to protect infants and young children against respiratory syncytial virus (RSV). Rationally designed live-attenuated RSV vaccines are in clinical development.
Karron RA +13 more
europepmc +2 more sources
Prospective study of live attenuated vaccines for patients receiving immunosuppressive agents. [PDF]
PLoS One, 2020 Patients receiving immunosuppressive agents are at risk of life-threatening infections. However, live vaccines are generally contraindicated in them. We conducted a prospective study regarding live attenuated vaccines for them.
Kamei K +8 more
europepmc +2 more sources
An Overview of Current Knowledge on in vitro Babesia Cultivation for Production of Live Attenuated Vaccines for Bovine Babesiosis in Mexico. [PDF]
Front Vet Sci, 2020 The instrumentation of the in vitro culture system has allowed researchers to learn more about the metabolic and growth behavior of Babesia spp. The various applications for in vitro cultivation of Babesia include obtaining attenuated strains for ...
Alvarez JA, Rojas C, Figueroa JV.
europepmc +2 more sources
Comparison of Immunogenicity and Protective Efficacy of PPR Live Attenuated Vaccines (Nigeria 75/1 and Sungri 96) Administered by Intranasal and Subcutaneous Routes. [PDF]
Vaccines (Basel), 2020 Following the successful eradication of rinderpest, the World Organization of Animal Health (OIE) and the Food and Agriculture Organization (FAO) have set a goal to eradicate peste des petits ruminants (PPR) globally by 2030.
Mahapatra M, Selvaraj M, Parida S.
europepmc +2 more sources
MicroRNA-Attenuated Virus Vaccines [PDF]
Non-Coding RNA, 2018 Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. The use of
Elizabeth J. Fay, R. Langlois
semanticscholar +4 more sources
Gut, 2021 Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether patients with inflammatory bowel disease treated with infliximab have attenuated ...
Nicholas A. Kennedy +2 more
exaly +2 more sources
Emerging Highly Virulent Porcine Epidemic Diarrhea Virus: Molecular Mechanisms of Attenuation and Rational Design of Live Attenuated Vaccines. [PDF]
Int J Mol Sci, 2019 The highly virulent porcine epidemic diarrhea virus (PEDV) emerged in China in 2010. It infects pigs of all ages, and causes severe diarrhea and high mortality rates in newborn pigs, leading to devastating economic losses in the pork industry worldwide ...
Hou Y, Wang Q.
europepmc +2 more sources
Attenuated Vaccines for Augmented Immunity. [PDF]
Cell Host & Microbe, 2017 Live attenuated vaccines are more immunogenic and have the capacity to elicit long-lasting immune responses. In two recent studies, Wang et al. (2017) and Si et al. (2016) describe strategies for the generation of live attenuated influenza viruses, which elicited robust humoral, mucosal, and cellular immunity against diverse virus strains.
S. Bournazos, J. Ravetch
semanticscholar +3 more sources
Preclinical and clinical experience with dupilumab on the correlates of live attenuated vaccines. [PDF]
J Allergy Clin Immunol Glob, 2022 Wechsler ME +15 more
europepmc +2 more sources
Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines [PDF]
Journal of Virology, 2018 Emergent coronaviruses remain a significant threat to global public health and rapid response vaccine platforms are needed to stem future outbreaks.
Vineet D. Menachery +9 more
semanticscholar +3 more sources