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Life-Threatening Infections Due to Live-Attenuated Vaccines: Early Manifestations of Inborn Errors of Immunity. [PDF]
Pöyhönen L +4 more
europepmc +2 more sources
Live attenuated vaccines against pertussis
The intensive use of pertussis vaccines has dramatically reduced the incidence of whooping cough during the 20th century. However, recent outbreaks in countries with high vaccination coverage illustrate the shortcomings of current vaccination regimens, and immunity induced by the most recent, acellular vaccines wanes much faster than anticipated. As an
C. Locht, N. Mielcarek
semanticscholar +3 more sources
Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3
Mouse experiments and deep sequencing confirmed that two additional live attenuated vaccine candidates against type 1 and 3 polioviruses remained attenuated and preserved all documented nOPV2 characteristics concerning genetic stability following ...
Ming-Te Yeh +7 more
semanticscholar +1 more source
Current Development and Challenges of Tetravalent Live-Attenuated Dengue Vaccines
Dengue is the most common arboviral disease caused by one of four distinct but closely related dengue viruses (DENV) and places significant economic and public health burdens in the endemic areas.
J. Hou, Weijian Ye, Jianzhu Chen
semanticscholar +1 more source
An overview on inactivated and live‐attenuated SARS‐CoV‐2 vaccines
After about 2 years since severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), first infections were detected in Wuhan city of China in December 2019, which was followed by a worldwide pandemic with a record of 5.41 million deaths. Due to urgent
S. Khoshnood +7 more
semanticscholar +1 more source
Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing Gn protects mice against rift valley fever virus [PDF]
Background: Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas. In addition, it is a potential biowarfare agent. Methodology/
A Jouan +58 more
core +4 more sources
Neutropenia as an adverse event following vaccination : results from randomized clinical trials in healthy adults and systematic review [PDF]
Background : In the context of early vaccine trials aimed at evaluating the safety profile of novel vaccines, abnormal haematological values, such as neutropenia, are often reported.
Aerssens, Annelies +10 more
core +4 more sources
Coronaviruses (CoVs) can infect a variety of hosts, including humans, livestock and companion animals, and pose a serious threat to human health and the economy.
Zhen Zhang +14 more
semanticscholar +1 more source
Protective immunity against Trypanosoma cruzi [PDF]
Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed.
Basombrío, Miguel Ángel Manuel +2 more
core +1 more source

