Results 71 to 80 of about 1,089,157 (267)

Attenuation effect and neutrino oscillation tomography

, 2017
Attenuation effect is the effect of weakening of contributions to the oscillation signal from remote structures of matter density profile. The effect is a consequence of integration over the neutrino energy within the energy resolution interval ...
Ioannisian, A. N., Smirnov, A. Yu.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine

Frontiers in Cellular and Infection Microbiology, 2018
Live attenuated vaccines are widely used to protect humans or animals from pathogen infections. We have previously developed a chicken embryo-attenuated Duck Hepatitis A Virus genotype 1 (DHAV-1) vaccine (CH60 strain).
Xumin Ou, Xumin Ou, Xumin Ou, Mingshu Wang, Mingshu Wang, Mingshu Wang, Sai Mao, Sai Mao, Jingyu Cao, Jingyu Cao, Anchun Cheng, Anchun Cheng, Anchun Cheng, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Renyong Jia, Renyong Jia, Renyong Jia, Mafeng Liu, Mafeng Liu, Mafeng Liu, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Xiaoyue Chen, Xiaoyue Chen, Maikel P. Peppelenbosch, Qiuwei Pan   +48 more
doaj   +1 more source

Attenuation and Phase Velocity of Elastic Wave in Textured Polycrystals with Ellipsoidal Grains of Arbitrary Crystal Symmetry

Acoustics, 2020
This study extends the second-order attenuation (SOA) model for elastic waves in texture-free inhomogeneous cubic polycrystalline materials with equiaxed grains to textured polycrystals with ellipsoidal grains of arbitrary crystal symmetry.
Gaofeng Sha
doaj   +1 more source

Ultrasound attenuation dependence on air compression or expansion processes [PDF]

, 2010
In this work variation of ultrasonic attenuation coefficient is analyzed in terms of air compression or expansion processes. In\ud closed spaces changing air volume, the ultrasound attenuation coefficient depends on thermodynamic processes which occur ...
Demcenko, A., Jakevicius, L., Mardosaite, R.   +2 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Non-dynamic origin of the acoustic attenuation at high frequency in glasses

, 1999
The sound attenuation in the THz region is studied down to T=16 K in glassy glycerol by inelastic x-ray scattering. At striking variance with the decrease found below 100 K in the GHz data, the attenuation in the THz range does not show any T dependence.
Di Leonardo, R., Fioretto, D., Krisch, M., Lorenzen, M., Masciovecchio, C., Monaco, G., Pignon, F., Ruocco, G., Scopigno, T., Sette, F.   +9 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Acoustic Attenuation in Fans and Ducts by Vaporization of Liquid Droplets [PDF]

, 1975
A cloud of small water droplets in saturated air attenuates acoustic disturbances by viscous drag, heat transfer, and vapor exchange with the ambient gas. The viscous and heat transfer phenomena attenuate at frequencies above 104 Hz for I-J.l droplets.
Candel, Sebastien M., Marble, Frank E.
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source