Results 151 to 160 of about 4,147,112 (315)

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

open access: yesAdvanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li   +10 more
wiley   +1 more source

Efficient Photothermoelectric Conversion of CSS@BP/Bi2Te3 Array for Innovative Aircraft Attitude Recognition

open access: yesAdvanced Science, EarlyView.
A chloroplast‐like CSS@BP composite with superior photothermoelectric conversion performance is synthesized via sonochemical methods. A portable Attitude Recognition Box (ARB) incorporating a CSS@BP/Bi2Te3 photothermal conversion array is developed, which achieves precise attitude recognition through bidirectional current detection induced by ...
Liangshutong Zhang   +5 more
wiley   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao   +11 more
wiley   +1 more source

Enhancing Grasping Function with a Thermoresponsive Ionogel Adhesive Glove for Patients with Rheumatic Diseases

open access: yesAdvanced Science, EarlyView.
This study presents a novel portable grasp‐assist glove, weighing only 47 g. The glove integrates smart adhesive pads and a hands‐free control interface based on IMU, designed to aid rheumatic patients with impaired hand function. The system enables switchable adhesion with independent control and detection of user release intent.
Shiqiang Wang   +11 more
wiley   +1 more source

Can Large Language Models Predict Associations Among Human Attitudes? [PDF]

open access: yesarXiv
Prior work has shown that large language models (LLMs) can predict human attitudes based on other attitudes, but this work has largely focused on predictions from highly similar and interrelated attitudes. In contrast, human attitudes are often strongly associated even across disparate and dissimilar topics.
arxiv  

A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells and Support to the Immune Cells by Epigenetic Regulation

open access: yesAdvanced Science, EarlyView.
A nanoregulator interfering with intratumoral methionine competition is designed to deliver oxaliplatin (IV) prodrugs and anti‐Lat4 small interfering RNA to tumor cells. This Pt (IV)‐crosslinked reduction‐sensitive nanoregulator progressively releases drugs within tumor cells and induces immunogenic cell death.
Boyu Su   +14 more
wiley   +1 more source

Bioinspired Mechanisms and Actuation of Soft Robotic Crawlers

open access: yesAdvanced Science, EarlyView.
Researchers have been developing soft materials and robotic crawlers inspired by soft‐bodied animals to mimic effective crawling in complex environments. This review explores the state‐of‐the‐art in soft crawlers, highlighting the interaction between materials, crawling mechanisms, actuation, and applications. The review concludes by providing insights
Min Pan   +6 more
wiley   +1 more source

Report of the Attitude Control and Attitude Determination Panel [PDF]

open access: yes
Failures and deficiencies in flight programs are reviewed and suggestions are made for avoiding them. The technology development problem areas considered are control configured vehicle design, gyros, solid state star sensors, control instrumentation ...

core   +1 more source

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