Results 181 to 190 of about 931,693 (302)

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

open access: yesEpilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh   +3 more
wiley   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

open access: yesEpilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze   +19 more
wiley   +1 more source

Perspectives on the burden of drug‐resistant epilepsy and treatment priorities: Findings from a multistakeholder survey

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) imposes a significant burden on patients and their caregivers. This study aimed to explore the concerns and perceptions of healthcare providers (HCPs), patients, and caregivers regarding the burden of disease and quality of life (QoL) in patients with DRE.
Simona Lattanzi   +6 more
wiley   +1 more source

A multicenter, video‐EEG‐based validation of a multimodal wearable device for focal seizure detection in adults: The SeizeIT2 study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Currently available wearable devices for detecting focal seizures primarily target major motor seizures or involve semi‐invasive subscalp implants. There is a pressing need for accurate, non‐invasive methods to detect diverse focal seizures for long‐term, out‐of‐hospital monitoring.
Lauren Swinnen   +19 more
wiley   +1 more source

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