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Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 [PDF]

The Lancet
Summary Background Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable ...
M. Naghavi +499 more
semanticscholar +4 more sources

Copper induces cell death by targeting lipoylated TCA cycle proteins

Science, 2022
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
P. Tsvetkov +17 more
semanticscholar +1 more source

Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice

Biology of Sex Differences, 2023
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic dysfunction-associated steatohepatitis (MASH) with a sexual dimorphism. Fertile women exhibit lower MASLD risk than men,
Carlos Cuño-Gómiz +7 more
doaj +1 more source

The ever‐increasing importance of cancer as a leading cause of premature death worldwide

Cancer, 2021
The relative importance of cardiovascular disease (CVD) and cancer as leading causes of premature death are examined in this communication. CVD and cancer are now the leading causes in 127 countries, with CVD leading in 70 countries (including Brazil and
F. Bray +3 more
semanticscholar +1 more source

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

Nature, 2020
Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approaches for the timely analysis of large datasets.
E. Williamson +29 more
semanticscholar +1 more source

Non Coding RNAs as Regulators of Wnt/β-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy

Biomedicines, 2022
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy histologically characterized by the replacement of myocardium by fibrofatty infiltration, cardiomyocyte loss, and inflammation.
Marina Piquer-Gil +5 more
doaj +1 more source

Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore

Cell Death and Disease, 2021
The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes bewildering, new roles for Par-4 are being reported.
Anees Rahman Cheratta +5 more
doaj +1 more source

In Vitro Veritas: From 2D Cultures to Organ-on-a-Chip Models to Study Immunogenic Cell Death in the Tumor Microenvironment

Cells, 2022
Immunogenic cell death (ICD) is a functionally unique form of cell death that promotes a T-cell-dependent anti-tumor immune response specific to antigens originating from dying cancer cells.
Dmitri V. Krysko +5 more
doaj +1 more source

Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species

Antioxidants, 2021
Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment.
Blanca Cucarull +7 more
doaj +1 more source

Kidney disease is associated with in-hospital death of patients with COVID-19

Kidney International, 2020
In December 2019, a coronavirus 2019 (COVID-19) disease outbreak occurred in Wuhan, Hubei Province, China, and rapidly spread to other areas worldwide. Although diffuse alveolar damage and acute respiratory failure were the main features, the involvement
Yi-chun Cheng +9 more
semanticscholar +1 more source

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