Results 81 to 90 of about 2,075,366 (204)

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases

Aggregate, Volume 7, Issue 3, March 2026.
Amyloid‐ID, a ThT‐like photocatalytic probe, enables proteotyping of amyloid deposits by ROS‐mediated protein labeling. Applied to patient biopsies, amyloid‐ID identifies potential fibrinogen‐derived amyloid in laryngeal amyloidosis, revealing a mechanically sensitive fibrillation mechanism linked to vocal cord friction.
Huan Feng, Fangliang Guo, Yan Wang, Meng You, Qiuxuan Xia, Wang Wan, Di Shen, Kaini Shen, Xin Zhang, Wei Li, Yu Liu   +10 more
wiley   +1 more source

Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis

JACC: Advances
Background: Delays in the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) contribute to the significant morbidity of the condition, especially in the era of disease-modifying therapies.
Jonathan Hourmozdi, MD, MSAI, MA, Nicholas Easton, MSAI, Simon Benigeri, MSAI, James D. Thomas, MD, Akhil Narang, MD, David Ouyang, MD, Grant Duffy, BS, Ross Upton, PhD, Will Hawkes, PhD, Ashley Akerman, PhD, Ike Okwuosa, MD, Adrienne Kline, MD, PhD, Abel N. Kho, MD, Yuan Luo, PhD, Sanjiv J. Shah, MD, Faraz S. Ahmad, MD, MS   +15 more
doaj   +1 more source

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin‐Mediated Amyloidosis: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Hereditary transthyretin‐mediated amyloidosis (hATTR) is a disorder that affects several body systems and can result in life‐threatening conditions like cardiomyopathy and polyneuropathy. For treatment of hATTR in the new medical realm, there is a breakthrough discovery of a medicine called Eplontersen, which targets the underlying ...
Zeel Vishnubhai Patel, Verkha Kumari, Paras, Bethineedi Lakshmi Deepak, Priyadarshi Prajjwal, Kolanu Nikhil Deep, Rakhi Bai, Serene Sara John, Omniat Amir Hussin   +8 more
wiley   +1 more source

Assessment of potential transthyretin amyloid cardiomyopathy cases in the Brazilian public health system using a machine learning model.

PLoS ONE
ObjectivesTo identify and describe the profile of potential transthyretin cardiac amyloidosis (ATTR-CM) cases in the Brazilian public health system (SUS), using a predictive machine learning (ML) model.MethodsThis was a retrospective descriptive database
Isabella Zuppo Laper, Cecilia Camacho-Hubner, Rafaela Vansan Ferreira, Claudenice Leite Bertoli de Souza, Marcus Vinicius Simões, Fabio Fernandes, Edileide de Barros Correia, Ariane de Jesus Lopes de Abreu, Guilherme Silva Julian   +8 more
doaj   +1 more source

99mTechnetium‐pyrophosphate scintigraphy: a practical guide for early diagnosis of transthyretin amyloid cardiomyopathy

ESC Heart Failure, 2022
Transthyretin amyloid cardiomyopathy (ATTR‐CM) is caused by the cardiac deposition of insoluble amyloid fibrils formed by misfolded transthyretin proteins and is associated with various cardiac symptoms, such as progressive heart failure, conduction ...
Nobuhiro Tahara, Olivier Lairez, Jin Endo, Atsushi Okada, Mitsuharu Ueda, Tomonori Ishii, Yoshinobu Kitano, Hahn‐Ey Lee, Eleonora Russo, Toru Kubo   +9 more
doaj   +1 more source

Prevalence of transthyretin amyloid cardiomyopathy in pacemaker patients [PDF]

Aims: Transthyretin amyloid cardiomyopathy (ATTR-CM) is characterized by increased wall thickness, diastolic dysfunction and progressive heart failure symptoms. The disease may infiltrate the conduction system leading to conduction disturbances requiring
Aaseth, Eirik, Christiansen, Jon Runar
core   +1 more source

Suspicion and referral of patients with transthyretin amyloid cardiomyopathy: Recommendations by a Portuguese multidisciplinary expert panel

Revista Portuguesa de Cardiologia
Early diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) is crucial for better disease management and outcome. To ensure timely diagnosis, a multidisciplinary panel of Portuguese experts, including cardiologists, internal medicine specialists ...
Dulce Brito, João Agostinho, Carlos Aguiar, Sílvia Aguiar Rosa, Nuno Cardim, Cândida Fonseca, Nuno Marques, Pedro Moraes Sarmento, Patrícia Rodrigues, Jonathan Santos, Maria João Vidigal Ferreira, Olga Azevedo   +11 more
doaj   +1 more source

Physics‐Informed, Differentiable Hydrologic Models for Capturing Unseen Extreme Events

Water Resources Research, Volume 62, Issue 2, February 2026.
Abstract Recently, a hybrid framework combining machine learning (ML) and process‐based equations, termed differentiable modeling, has shown comparable accuracy to pure ML models while offering enhanced interpretability and spatial generalizability. However, it remained unclear how well hybrid models generalize to extreme floods outside of the range of
Yalan Song, Kamlesh Sawadekar, Jonathan M. Frame, Ming Pan, Martyn P. Clark, Wouter J. M. Knoben, Andrew W. Wood, Kathryn E. Lawson, Trupesh Patel, Chaopeng Shen   +9 more
wiley   +1 more source

Navigating the Lead Paradox: Successful Co‐Implantation of Cardiac Contractility Modulation Device and a Micra Leadless Pacemaker

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 2, Page 434-437, February 2026.
This central illustration visually summarizes the first co‐implantation of a Cardiac Contractility Modulation (CCM) system and a Micra leadless pacemaker in a 78‐year‐old male with wild‐type transthyretin cardiac amyloidosis and NYHA Class III heart failure.
Gabriele Pavani, Paolo Garrone, Gianpaolo Varalda, Antonino Previti, Matteo Bianco, Alessandra Chinaglia   +5 more
wiley   +1 more source