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Therapy of ATTR Cardiac Amyloidosis: Current Indications
Current Problems in Cardiology, 2023Transthyretin cardiac amyloidosis is a restrictive cardiomyopathy caused by extracellular deposition in the heart of amyloid fibrils derived from plasma transthyretin (ATTR), either in its hereditary (ATTRh) or acquired (ATTRwt) forms. Cardiac amyloidosis has a very poor prognosis if therapy is not started promptly.
Di Lisi, Daniela +4 more
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The Swedish landscape of hereditary ATTR amyloidosis
Amyloid, 2017Northern Sweden is a well-known clustering area for hereditary transthyretin (TTR) amyloid (ATTR) amyloidosis caused by the Val30Met mutation.
Ole B, Suhr +4 more
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Inotersen treatment for ATTR amyloidosis
Amyloid, 2019Until recently there has been limited specific therapy for transthyretin amyloidosis (ATTR). One possible therapy is to reduce the availability of the protein precursor necessary for amyloid fibril...
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Therapy of ATTR amyloidosis: perspective
Amyloid, 2011Abstract: Although liver transplantation is the only therapy to halt the clinical manifestations of transthyretin (TTR) related familial amyloidotic polyneuropathy (FAP), the therapy has given rise...
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[Neurological manifestations of ATTR amyloidosis].
Innere Medizin (Heidelberg, Germany), 2023Transthyretin amyloidosis (ATTR) is a rare disease in which the protein transthyretin (TTR) is deposited in the form of amyloid fibrils in various tissues and organs and secondarily leads to functional impairment, especially in peripheral nerves and the heart. A differentiation is made between hereditary and sporadic forms.
Helena F, Pernice, Katrin, Hahn
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The challenging histological diagnosis of transthyretin (ATTR) amyloidosis
Amyloid, 2017In all kinds of amyloidosis, diagnosis depends on a biopsy, e.g. from subcutaneous adipose tissue (SAT) of abdomen.
Ellahe, Charkhkar, Per, Westermark
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Association between hearing loss and hereditary ATTR amyloidosis
Amyloid, 2019Background: Hereditary transthyretin (TTR) related amyloidosis (ATTRv) is a life-threatening condition, which can potentially affect all organs. The objective was to identify the hearing status of patients with cardiac ATTRv and describe their audiological pattern.
Sophie Bartier +8 more
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Familial case of hereditary transthyretin amyloidosis with polyneuropathy (ATTR amyloidosis)
Nauchno-prakticheskii zhurnal «Medicinskaia genetika, 2023Приводится описание семейного случая наследственного транстиретинового амилоидоза. Проведено клиническое обследование и молекулярно-генетическое тестирование пациента 50 лет, его родного брата 44 лет и его сына 30 лет с симптомами полинейропатии, нарушением пищеварения и мочеиспускания.
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Genotype-Phenotype Correlations in ATTR Amyloidosis
Heart Failure Clinics: Hereditary transthyretin-related amyloidosis (hATTR) is the most common form of familial amyloidosis. It is an autosomal dominant disease caused by a pathogenic variant in the TTR gene. More than 140 TTR gene variants have been associated with hATTR, with the Val30Met variant representing the most common worldwide.
Monda, Emanuele +8 more
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