Results 71 to 80 of about 489,224 (288)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Some Rural Attractions which Attract Tourists

Asian Journal of Agriculture and Rural Development, 2019
Developing rural tourism is a comprehensive strategy for improving the rural economy. The Structure Equation Model (SEM) approach was applied to test how attraction and experiential values of a rural region affect the tourists’ satisfaction and their decision to revisit. After interviewing 353 tourists during their trip to Hakka County, Miaoli, Taiwan,
Shu-Yi Chi, Biing-Wen Huang, Han Xing Luo   +2 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Enhancements in Clinical Practice in the Contemporary Landscape of Male Facial Attractiveness

Dermato
The concept of gender has evolved significantly in recent decades, moving from a binary status to a multiplicity of gender types. In today’s world, the new reality of the concept of masculinity, as defined socially and historically, must be recognized ...
Javier Anido, Nozay Guzmán, Marta Serna, Jesús Quero, Pedro Santos   +4 more
doaj   +1 more source

The volume and source of cyberabuse influences victim blame and perceptions of attractiveness [PDF]

, 2018
Cyberabuse is an escalating problem in society, as opportunities for abuse to occur in online public domains increase. Such acts are often defined by the frequency of abuse, and in many cases multiple individuals play a part in the abuse.
Hand, Christopher J., Scott, Graham G., Wiencierz, Stacey   +2 more
core   +3 more sources

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Conflict and Compatibility Between City Branding and Urban Competitiveness: Developing and Applying a Multidimensional Index for Emerging Cities in the MENA Region

Architecture
This research develops a city Branding–Competitiveness Index (BCI) that comprehend symbolic city branding elements with quantifiable aspects of urban competitiveness.
Nada H. Abdelraouf, Amal Abdel-Latif, Tamer ElSerafi   +2 more
doaj   +1 more source

Health at the ballot box: disease threat does not predict attractiveness preference in British politicians [PDF]

Royal Society Open Science, 2016
According to disease avoidance theory, selective pressures have shaped adaptive behaviours to avoid people who might transmit infections. Such behavioural immune defence strategies may have social and societal consequences. Attractiveness is perceived as
Gustav Nilsonne, Adam Renberg, Sandra Tamm, Mats Lekander   +3 more
doaj   +1 more source

The dark side of employee referral bonus programs : potential applicants’ awareness of a referral bonus and perceptions of organizational attractiveness [PDF]

, 2017
The purpose of this study is to examine the effects of potential applicants’ awareness of employees being rewarded for referrals on organizational attractiveness, based on credibility theory and the multiple inference model.
Carpentier, Marieke, Stockman, Sara, Van Hoye, Greet   +2 more
core   +2 more sources