Results 131 to 140 of about 32,946 (310)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ON ATTRACTOR FLOW AND SMALL BLACK HOLES [PDF]
, 2011 We study the attractor flow and near horizon geometry of two-charge small black holes in heterotic string theory. The Hessian of Sen's entropy function with respect to the moduli fields has standard attractor properties and shows the interesting ...
BHUPENDRA NATH TIWARI, SANJAY SIWACH
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Black hole attractors and the entropy function in four- and five-dimensional N=2 supergravity [PDF]
, 2007 Extremal black holes in theories of gravity coupled to abelian gauge fields and neutral scalars, such as those arising in the low-energy description of compactifications of string theory on Calabi-Yau manifolds, exhibit the attractor phenomenon: on the ...
Perz, Jan
core
Chaotic Attractor Generation via Space Function Controls [PDF]
, 2011 The analysis of chaotic attractor generation is given, and the generation of novel chaotic attractor is introduced in this paper. The underlying mechanism involves two simple linear systems with one-dimensional, two-dimensional, or three-dimensional ...
Guangming Xie +5 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
On the Dynamics of Immune-Tumor Conjugates in a Four-Dimensional Tumor Model
MathematicsWe examine the ultimate dynamics of the four-dimensional model describing interactions between host cells, immune cells, tumor cells, and immune-tumor conjugate cells proposed by Abernethy and Gooding in 2018.
Konstantin E. Starkov +1 more
doaj +1 more source