Results 91 to 100 of about 10,724 (247)
RUDN Journal of Political ScienceThe relevance of the topic presented in the article is determined primarily by the current foreign policy situation, namely the hybrid war unleashed by the collective West against the Russian Federation, a significant component of which are the so-called
Alexander V. Kurochkin
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
THE SYNERGETIC CONTROL SYNTHESIS FOR AIRCRAFT MOTION ALONG REFERENCE PATH IN HORIZONTAL PLANE
Современная наука и инновации, 2022 Article is devoted to the solution of a problem of feedback control synthesis for the aircraft. This control provides the movement of the aircraft on a reference path of flight in the horizontal plane.
Andrei Nickolaevitch Popov
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Modeling Networks of Four Elements
ComputationIn this article, fourth-order systems of ordinary differential equations are studied. These systems are of a special form, which is used in modeling gene regulatory networks.
Olga Kozlovska, Felix Sadyrbaev
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Polynomial $\alpha$-attractors
, 2022 Inflationary $\alpha$-attractor models can be naturally implemented in supergravity with hyperbolic geometry. They have stable predictions for observables, such as $n_s=1-{2/ N_e} $, assuming that the potential in terms of the original geometric variables, as well as its derivatives, are not singular at the boundary of the hyperbolic disk, or half ...
Kallosh, Renata, Linde, Andrei
openaire +2 more sources