Results 91 to 100 of about 87,240 (291)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Critical Kauffman networks under deterministic asynchronous update

, 2007
We investigate the influence of a deterministic but non-synchronous update on Random Boolean Networks, with a focus on critical networks. Knowing that ``relevant components'' determine the number and length of attractors, we focus on such relevant ...
Aldana-Gonzalez M, Alexander J Mc, Barbara Drossel, Derrida B, Florian Greil, Gershenson C, Harvey I, Joost Sattler, Klemm K   +8 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Global Attractor of the Allen-Cahn Equation on the Sphere

Frontiers in Applied Mathematics and Statistics, 2020
In this paper we study the attractor of a parabolic semiflow generated by a singularly perturbed PDE with a non-linear term given by a bistable potential, in an oval surface; the Allen-Cahn equation being a prototypical example.
David Medina, Pablo Padilla
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Uniform attractors for non-autonomous wave equations with nonlinear damping

, 2006
We consider dynamical behavior of non-autonomous wave-type evolutionary equations with nonlinear damping, critical nonlinearity, and time-dependent external forcing which is translation bounded but not translation compact (i.e., external forcing is not ...
Chepyzhov V. V., Chepyzhov V. V., Chepyzhov V. V., Chunyou Sun, Daomin Cao, Jinqiao Duan, Pata V.   +6 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The dimension of the boundary of the Lévy Dragon

International Journal of Mathematics and Mathematical Sciences, 1997
In this paper we describe the computations done by the authors in determining the dimension of the boundary of the Lévy Dragon. A general theory was developed for calculating the dimension of a self-similar tile and the theory was applied to this ...
P. Duvall, J. Keesling
doaj   +1 more source