Results 61 to 70 of about 7,186,072 (303)
Journal of Infection and Public Health, 2020 Background: The aim of this study was to estimate the attributable risk for all-cause mortality in hypertensive adults living in Beijing, China. Methods: We conducted a prospective cohort study on the basis of the disease risk prediction model, which ...
Weiwei Sun +8 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Estimating the burden of disease attributable to childhood and maternal undernutrition in South Africa in 2000 [PDF]
, 2007 OBJECTIVES \ud \ud To estimate the disease burden attributable to being underweight as an indicator of undernutrition in children under 5 years of age and in pregnant women for the year 2000.\ud \ud DESIGN\ud \ud World Health Organization comparative ...
Hendricks, Michael +4 more
core
Studies reporting total population attributable risk for stroke.
, 2014 Studies reporting total population attributable risk for stroke.
Albert Hofman (107303) +3 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
SAS Macros for Calculation of Population Attributable Fraction in a Cohort Study Design [PDF]
The population attributable fraction (PAF) is a useful measure for quantifying the impact of exposure to certain risk factors on a particular outcome at the population level.
Esa Virtala +4 more
core
Number of deaths attributable to different risk factors ofCKD in 2019.
, 2023 Number of deaths attributable to different risk factors ofCKD in 2019.
Bikram Adhikari (10905898) +3 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
On robust and efficient designs for risk estimation in epidemiologic studies [PDF]
We consider the design problem for the estimation of several scalar measures suggested in the epidemiological literature for comparing the success rate in two samples.
Dette, Holger
core