Results 71 to 80 of about 394,213 (310)

Incidence and risk of chronic obstructive pulmonary disease in a Korean community-based cohort

open access: yesInternational Journal of COPD, 2018
Ah Young Leem,1 Boram Park,2 Young Sam Kim,1 Ji Ye Jung,1 Sungho Won2 1Division of Pulmonology, Department of Internal Medicine, Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Epidemiology ...
Leem AY, Park B, Kim YS, Jung JY, Won S
doaj  

Outcome after stroke attributable to baseline factors-The PROSpective Cohort with Incident Stroke (PROSCIS).

open access: yesPLoS ONE, 2018
BackgroundThe impact of risk factors on poor outcome after ischemic stroke is well known, but estimating the amount of poor outcome attributable to single factors is challenging in presence of multimorbidity.
Carolin Malsch   +7 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

The concept of risk factors in assessing the impact of smoking on an exacerbation of chronic obstructive pulmonary disease

open access: yesТерапевтический архив, 2015
Aim. By using the risk concept, to determine a quantitative relationship between smoking in patients with chronic obstructive pulmonary disease (COPD) and the development of an exacerbation. Subjects and methods.
O V Zhukova   +2 more
doaj  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Mortalidad atribuible al consumo de tabaco en México

open access: yesSalud Pública de México, 2002
Objetivo. Estudiar la asociación entre defunciones registradas en la delegación Coyoacán y consumo de tabaco y alcohol. Material y métodos. Estudio de mortalidad proporcional y determinación de fracción atribuible en una cohorte de sujetos de la ciudad ...
Pablo Kuri-Morales   +3 more
doaj  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Corrigendum: How often is occult atrial fibrillation in cryptogenic stroke causal vs. incidental? A meta-analysis

open access: yesFrontiers in Neurology, 2023
Napasri Chaisinanunkul   +7 more
doaj   +1 more source

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