Results 111 to 120 of about 122,790 (284)

Self-healing hybrid intrusion detection system: an ensemble machine learning approach

open access: yesDiscover Artificial Intelligence
The increasing complexity and adversity of cyber-attacks have prompted discussions in the cyber scenario for a prognosticate approach, rather than a reactionary one.
Sauharda Kushal   +3 more
doaj   +1 more source

PKI Scalability Issues

open access: yes, 2004
This report surveys different PKI technologies such as PKIX and SPKI and the issues of PKI that affect scalability. Much focus is spent on certificate revocation methodologies and status verification systems such as CRLs, Delta-CRLs, CRS, Certificate ...
Bonilla, Rafael, Slagell, Adam J
core   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

The ERA of FOLE: Foundation

open access: yes, 2015
This paper discusses the representation of ontologies in the first-order logical environment FOLE (Kent 2013). An ontology defines the primitives with which to model the knowledge resources for a community of discourse (Gruber 2009).
Kent, Robert E.
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Carbon isotope budget indicates biological disequilibrium dominated ocean carbon storage at the Last Glacial Maximum

open access: yesNature Communications
Understanding the causes of the  ~90 ppmv atmospheric CO2 swings between glacial and interglacial climates is an important open challenge in paleoclimate research.
Anne Willem Omta   +3 more
doaj   +1 more source

The FOLE Table

open access: yes, 2018
This paper continues the discussion of the representation of ontologies in the first-order logical environment FOLE. According to Gruber, an ontology defines the primitives with which to model the knowledge resources for a community of discourse.
Kent, Robert E.
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Tunable superconducting diode effect in higher-harmonic InSb nanosheet interferometers

open access: yesNew Journal of Physics
Superconducting diodes, characterized by the nonreciprocal supercurrent flow, have gained significant attention for their potential in dissipationless electronics.
Xingjun Wu   +7 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

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