Results 91 to 100 of about 765,630 (290)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Evidence for a Low-Spin to Intermediate-Spin State Transition in LaCoO3

, 2005
We present measurements of the magnetic susceptibility and of the thermal expansion of a LaCoO$_3$ single crystal. Both quantities show a strongly anomalous temperature dependence.
A. Revcolevschi, C. Martin, C. Zobel, D. Akahoshi, D. Bruns, D. Foerster, E. Suard, G. Thornton, G.H. Jonker, Hua Wu, J. Baier, J. Wang, J.-P. Doumerc, K. Asai, K. Asai, K. Miyatani, M. Abbate, M. Grüninger, M. Itoh, M. Kriener, M. Respaud, M.A. Korotin, M.A. Señaris Rodríguez, P. Reutler, P.M. Raccah, R.D. Shannon, R.H. Potze, S. Roy, S. Stølen, S. Yamaguchi, S. Yamaguchi, T. Lorenz, T. Saitoh, T. Vogt, V.G. Bhide, Y. Kobayashi, Y. Moritomo   +36 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Neighbourhood systems based attribute reduction in formal decision contexts

CAAI Transactions on Intelligence Technology, 2019
Attribute reduction of formal decision context mainly uses the relationship between two concept lattices generated by the condition and decision attributes to remove redundant condition attributes.
Xiaohe Zhang, Jusheng Mi, Meizheng Li, Meishe Liang   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Parallel Attribute Reduction Algorithm for Complex Heterogeneous Data Using MapReduce

Complexity, 2018
Parallel attribute reduction is one of the most important topics in current research on rough set theory. Although some parallel algorithms were well documented, most of them are still faced with some challenges for effectively dealing with the complex ...
Tengfei Zhang, Fumin Ma, Jie Cao, Chen Peng, Dong Yue   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Optimizing Attribute Reduction in Multi-Granularity Data through a Hybrid Supervised–Unsupervised Model

Mathematics
Attribute reduction is a core technique in the rough set domain and an important step in data preprocessing. Researchers have proposed numerous innovative methods to enhance the capability of attribute reduction, such as the emergence of multi ...
Zeyuan Fan, Jianjun Chen, Hongyang Cui, Jingjing Song, Taihua Xu   +4 more
doaj   +1 more source

Approximate Accuracy Approaches to Attribute Reduction for Information Systems

Abstract and Applied Analysis, 2014
The key problem for attribute reduction to information systems is how to evaluate the importance of an attribute. The algorithms are challenged by the variety of data forms in information system.
Deshan Liu, Dapeng Wang, Deqin Yan, Yu Sang   +3 more
doaj   +1 more source