Results 111 to 120 of about 10,917,671 (339)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Wavelet Packet and Granular Computing With Application to Communication Emitter Recognition

open access: yesIEEE Access, 2019
Individual recognition of communication emitter can obtain the working mechanism, system parameters, and the usage model of the emitters based on the separation and interception of the specific emitter signals.
Ping Sui   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Multigranulations Rough Set Method of Attribute Reduction in Information Systems Based on Evidence Theory

open access: yes, 2014
Attribute reduction is one of the most important problems in rough set theory. However, from the granular computing point of view, the classical rough set theory is based on a single granulation.
Minlun Yan
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Increment Attributes set Reduction Algorithm of Information System Based on Rough Set Theory

open access: yes, 2010
[[abstract]]With regard to amplified dynamic reduction algorithm, previous studies by scholars (Liu Zongtian, 1999; Chen Yunhua, Ye Dongyi, 2002; Li Yinhua, Li Deyu and Zhang Jifu, 2004) had focused on object increment without taking attribute increment ...
Yu-Shien Ho
core  

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

A novel method to attribute reduction based on weighted neighborhood probabilistic rough sets

open access: yesInternational Journal of Approximate Reasoning, 2022
Jingjing Xie, Bao-Qing Hu, Haibo Jiang
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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