Results 61 to 70 of about 846,763 (295)

The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random [PDF]

, 2011
Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke “design ...
Bai, Chunyan Y., Espinosa, Avelina, Paz-y-Miño C, Guillermo   +2 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Feature Selection in Decision Systems Based on Conditional Knowledge Granularity [PDF]

International Journal of Computational Intelligence Systems, 2011
Feature selection is an important technique for dimension reduction in machine learning and pattern recognition communities. Feature evaluation functions play essential roles in constructing feature selection algorithms.
Tingquan Deng, Chengdong Yang, Qinghua Hu   +2 more
doaj   +1 more source

Using Feature Weights to Improve Performance of Neural Networks [PDF]

, 2011
Different features have different relevance to a particular learning problem. Some features are less relevant; while some very important. Instead of selecting the most relevant features using feature selection, an algorithm can be given this knowledge of
Iqbal, Ridwan Al
core  

Experimental Evidence for Selection Rules in Multiphoton Double Ionization of Helium

, 2018
We report on the observation of phase space modulations in the correlated electron emission after strong field double ionization of helium using laser pulses with a wavelength of 394~nm and an intensity of $3\cdot10^{14}$W/cm$^2$.
Dörner, R., Eckart, S., Hartung, A., Henrichs, K., Jahnke, T., Kang, H., Kunitski, M., Pitzer, M., Richter, M., Rist, J., Sann, H., Schöffler, M. S., Trabert, D.   +12 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Graph Estimation From Multi-attribute Data [PDF]

, 2013
Many real world network problems often concern multivariate nodal attributes such as image, textual, and multi-view feature vectors on nodes, rather than simple univariate nodal attributes.
Kolar, Mladen, Liu, Han, Xing, Eric P.
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Auditing Black-box Models for Indirect Influence

, 2016
Data-trained predictive models see widespread use, but for the most part they are used as black boxes which output a prediction or score. It is therefore hard to acquire a deeper understanding of model behavior, and in particular how different features ...
Adler, Philip, Falk, Casey, Friedler, Sorelle A., Rybeck, Gabriel, Scheidegger, Carlos, Smith, Brandon, Venkatasubramanian, Suresh   +6 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source