Results 101 to 110 of about 3,334,963 (348)

„Oblężenie i obrona Saragossy” Józefa Mrozińskiego a tradycja narracji heroicznej

open access: yesStylistyka, 2019
The detailed studies conducted in the article are based on the issue of heroic narrative. Heroic narrative is a type of writing concerning serious subjects significant to the Polish identity, cultural context and national history.
MARZANNA UŹDZICKA
doaj  

Attribution Required: Stack Overflow Code Snippets in GitHub Projects

open access: yes, 2017
Stack Overflow (SO) is the largest Q&A website for developers, providing a huge amount of copyable code snippets. Using these snippets raises various maintenance and legal issues.
Baltes, Sebastian   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

An Argumentation-Based Reasoner to Assist Digital Investigation and Attribution of Cyber-Attacks

open access: yes, 2020
We expect an increase in the frequency and severity of cyber-attacks that comes along with the need for efficient security countermeasures. The process of attributing a cyber-attack helps to construct efficient and targeted mitigating and preventive ...
Karafili, Erisa   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

A Theory of Attribution [PDF]

open access: yes
Attribution of economic joint effects is achieved with a random order model of their relative importance. Random order consistency and elementary axioms uniquely identify linear and proportional marginal attribution.
Feldman, Barry
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Authorship Attribution Using a Neural Network Language Model

open access: yes, 2016
In practice, training language models for individual authors is often expensive because of limited data resources. In such cases, Neural Network Language Models (NNLMs), generally outperform the traditional non-parametric N-gram models.
Ge, Zhenhao   +2 more
core   +1 more source

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