Results 51 to 60 of about 3,380,404 (320)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Biosynthesis of Gold Nanoparticles Using Green Alga Pithophora oedogonia with Their Electrochemical Performance for Determining Carbendazim in Soil

International Journal of Electrochemical Science, 2016
Biosynthesis nanomaterial have constituted a huge attention recently due to its non-toxic process. In this work, we demonstrated the biosynthesis of Au nanoparticles using green algae Pithophora. oedogonia as reducing agent.
Lei Li, Zunju Zhang
doaj   +1 more source

Short-Chained Oligo(Ethylene Oxide)-Functionalized Gold Nanoparticles: Realization Of Significant Protein Resistance [PDF]

, 2017
Protein corona formed on nanomaterial surfaces play an important role in the bioavailability and cellular uptake of nanomaterials. Modification of surfaces with oligoethylene glycols (OEG) are a common way to improve the resistivity of nanomaterials to ...
Riley, Kathryn R., Sims, C. M., Vanderah, D. J., Walker, M. L., Wood, I. T.   +4 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Electroconductive π-Junction Au Nanoparticles [PDF]

Bulletin of the Chemical Society of Japan, 2012
Abstract The fabrication of printed electronic circuits using solution-based electroconductive materials at low temperature is essential for the realization of modern printed electronics including transistors, photovoltaic cells, and light-emitting devices.
Kanehara, Masayuki, Takeya, Jun, Uemura, Takafumi, Murata, Hideyuki, Takimiya, Kazuo, Sekine, Hikaru, Teranishi, Toshiharu   +6 more
openaire   +2 more sources

Enhanced photocatalytic activity of Bi4Ti3O12 nanosheets by Fe3+-doping and the addition of Au nanoparticles: Photodegradation of Phenol and bisphenol A

, 2017
Pure Bi 4 Ti 3 O 12 (BTO) and Fe-doped Bi 4 Ti 3 O 12 (Fe/BTO) nanosheets with exposed {001} facets were synthesized by a one-step molten salt method. Au nanoparticles with a diameter range of 20–50 nm were loaded on 2%Fe-doped Bi 4 Ti 3 O 12 (Au-2%Fe ...
Yongbao Liu, G. Zhu, Jianzhi Gao, M. Hojamberdiev, Runliang Zhu, Xiumei Wei, Q. Guo, Peng Liu   +7 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Design of sensitive electrochemical sensor as the analytical tool for methyldopa in drug and biological samples [PDF]

شیمی کاربردی روز, 2019
In this work, an electrochemical sensor based on carbon paste electrode modified with Au nanoparticle and 1-methyl-3-octylimidazolium chloride was fabricated as a sensor for determination of methyldopa.
Maryam Abbasghorbani
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Fabrication of Hollow AlAu2 Nanoparticles by Solid State Dewetting and Oxidation of Al on Sapphire Substrate

, 2018
The Al-Au binary diffusion couple is a classic example of the system exhibiting Kirkendall voiding during interdiffusion. We demonstrate that this effect, which is a major reason for failures of the wire bonds in microelectronics, can be utilized for ...
Gazit, Nimrod, Klinger, Leonid, Rabkin, Eugen, Richter, Gunther, Sharma, Amit   +4 more
core   +1 more source