Results 51 to 60 of about 601,814 (301)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Other title: Auditor of State operations during the COVID-19 declaration of emergency
, 2020 "Ohio Auditor of State, Keith Faber."; At head of title: Auditor of State advisory memo; "To: All local governments, public offices and independent public accountants."; "March 13, 2020."As Ohio and the nation respond to the COVID-19 virus outbreak, the ...
Ohio. Auditor of State
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Auditor Quality and Discretionary Accruals: Case of Australian Listed Companies
Jurnal Akuntansi dan Auditing Indonesia, 2010 This study empirically examines the relation between two dimensions of auditor quality: auditor independence and auditor specialization, and the level of discretionary accruals, a proxy for earnings management.
Rusmin Rusmin
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
THE EFFECT OF AUDITOR EXPERIENCE, TASK COMPLEXITY, AND AUDITOR INDEPENDENCE ON AUDIT JUDGMENT
SAR (Soedirman Accounting Review): Journal of Accounting and BusinessThe quality of audit judgment is the most important factor to ensure the accuracy and credibility of financial statements. Therefore, this study aims to determine the effect of auditor experience, task complexity, and auditor independence on audit ...
Angeliani Angeliani
doaj +1 more source
Auditors’ and auditees’ perception on the internal audit quality
Audit Financiar, 2016 The purpose of this study is to examine the influence of audit planning, fieldwork audit, audit reporting, follow-up action of the audit results, the auditor team competence, and independence of the auditor team on the internal audit quality at the ...
Kartika Djati +3 more
doaj +1 more source
The Independence Of The European Court Of Auditors
Common Market Law Review, 2019 This article considers the independence of the European Court of Auditors (ECA) from a formal, legal perspective. It argues that the primary constitutional justification behind such independence is the ECA’s need to act on behalf of and defend the EU interest.
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source